The Colony-stimulating Factors and Cancer

Overview

Journal Nat Rev Cancer

Specialty Oncology

Date 2010 May 25

PMID 20495576

Citations 76

Authors

Donald Metcalf

Affiliations

Soon will be listed here.

Abstract

The four colony-stimulating factors (CSFs) are glycoproteins that regulate the generation and some functions of infection-protective granulocytes and macrophages. Recombinant granulocyte-CSF (G-CSF) and granulocyte-macrophage-CSF (GM-CSF) have now been used to increase dangerously low white blood cell levels in many millions of cancer patients following chemotherapy. These CSFs also release haematopoietic stem cells to the peripheral blood, and these cells have now largely replaced bone marrow as more effective populations for transplantation to cancer patients who have treatment-induced bone marrow damage.

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