Adipose Tissue and Hematopoiesis: Friend or Foe?

Overview

Journal J Clin Lab Anal

Publisher Wiley

Specialties Biomedical Engineering
Biotechnology
Pathology

Date 2023 Mar 27

PMID 36972475

Authors

Na He

Min Liu

Yue Wu

Affiliations

Soon will be listed here.

Abstract

Aim: Hematopoietic stem cells are the origin of all hematopoietic cells. They have the self-renewal ability and can differentiate into various blood cells. In physiological state, most of the hematopoietic stem cells are dormant, and only a few cells proliferate to maintain hematopoietic homeostasis.

Methods: This precise steady-state maintenance is regulated by complex mechanisms. Bone marrow adipocytes make up half of all cells in the bone marrow cavity, a feature that has attracted the attention of researchers from multiple fields. The adipocyte density within marrow increases during aging and obesity.

Results: Recent studies have shown that bone marrow adipocytes play important roles in regulating hematopoiesis, but the effects of bone marrow adipocytes on hematopoiesis are often conflicting. Bone marrow adipocytes, participating in the formation of bone marrow hematopoietic microenvironment, influence hematopoiesis positively or negatively. In addition, other adipose tissue, especially white adipose tissue, also regulates hematopoiesis.

Conclusion: In this review, we describe the role of adipose tissue in hematological malignancies, which may be useful for understanding hematopoiesis and the pathogenesis of related diseases.

Citing Articles

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Cellular crosstalk in the bone marrow niche.

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Adipose tissue and hematopoiesis: Friend or foe?.

He N, Liu M, Wu Y J Clin Lab Anal. 2023; 37(6):e24872.

PMID: 36972475 PMC: 10156104. DOI: 10.1002/jcla.24872.

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