Plexin-B1 Mutation Drives Metastasis in Prostate Cancer Mouse Models

Overview

Journal Cancer Res Commun

Specialty Oncology

Date 2023 Mar 20

PMID 36936664

Authors

Boris Shorning

Neil Trent

David F Griffiths

Thomas Worzfeld

Stefan Offermanns

Matthew J Smalley

Magali Williamson

Affiliations

Soon will be listed here.

Abstract

Significance: Few therapeutic targets have been identified specifically for preventing locally invasive/oligometastatic prostate cancer from becoming more widely disseminated. Our findings suggest Plexin-B1 signaling, particularly from the clinically relevant mutant, is such a target.

Citing Articles

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The metastasis-promoting P1597L mutation in PlexinB1 enhances Ras activity.

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