Photobiomodulation Provides Neuroprotection Through Regulating Mitochondrial Fission Imbalance in the Subacute Phase of Spinal Cord Injury

Overview

Journal Neural Regen Res

Date 2023 Mar 17

PMID 36926726

Authors

Xin Li

Xuan-Kang Wang

Zhi-Jie Zhu

Zhuo-Wen Liang

Peng-Hui Li

Yang-Guang Ma

Tan Ding

Kun Li

Xiao-Shuang Zuo

Cheng Ju

Zhi-Hao Zhang

Zhi-Wen Song

Hui-Lin Quan

Jia-Wei Zhang

Liang Luo

Zhe Wang

Xue-Yu Hu

Affiliations

Soon will be listed here.

Abstract

Increasing evidence indicates that mitochondrial fission imbalance plays an important role in delayed neuronal cell death. Our previous study found that photobiomodulation improved the motor function of rats with spinal cord injury. However, the precise mechanism remains unclear. To investigate the effect of photobiomodulation on mitochondrial fission imbalance after spinal cord injury, in this study, we treated rat models of spinal cord injury with 60-minute photobiomodulation (810 nm, 150 mW) every day for 14 consecutive days. Transmission electron microscopy results confirmed the swollen and fragmented alterations of mitochondrial morphology in neurons in acute (1 day) and subacute (7 and 14 days) phases. Photobiomodulation alleviated mitochondrial fission imbalance in spinal cord tissue in the subacute phase, reduced neuronal cell death, and improved rat posterior limb motor function in a time-dependent manner. These findings suggest that photobiomodulation targets neuronal mitochondria, alleviates mitochondrial fission imbalance-induced neuronal apoptosis, and thereby promotes the motor function recovery of rats with spinal cord injury.

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