High-Fat Diet Aggravates the Disorder of Glucose Metabolism Caused by Chlorpyrifos Exposure in Experimental Rats

Overview

Journal Foods

Specialty Biotechnology

Date 2023 Feb 25

PMID 36832892

Authors

Jinwang Li

Xiude Li

Zhihui Zhang

Weilong Cheng

Guangmin Liu

Guoping Zhao

Affiliations

Soon will be listed here.

Abstract

Epidemiological research has demonstrated that the increase in high fat consumption has promoted the morbidity of diabetes. Exposure to organophosphorus pesticides (such as chlorpyrifos) may also increase the risk of diabetes. Although chlorpyrifos is a frequently detected organophosphorus pesticide, the interaction effect between chlorpyrifos exposure and a high-fat diet on glucose metabolism is still unclear. Thus, the effects of chlorpyrifos exposure on glucose metabolism in rats eating a normal-fat diet or a high-fat diet were investigated. The results demonstrated that the glycogen content in the liver decreased and that the glucose content increased in chlorpyrifos-treated groups. Remarkably, the ATP consumption in the chlorpyrifos-treatment group was promoted in the rats eating a high-fat diet. However, chlorpyrifos treatment did not change the serum levels of insulin and glucagon. Notably, the contents of liver ALT and AST changed more significantly in the high-fat chlorpyrifos-exposed group than in the normal-fat chlorpyrifos-exposed group. Chlorpyrifos exposure caused an increase in the liver MDA level and a decrease in the enzyme activities of GSH-Px, CAT, and SOD, and the changes were more significant in the high-fat chlorpyrifos-treatment group. The results indicated that chlorpyrifos exposure led to disordered glucose metabolism in all dietary patterns as a result of antioxidant damage in the liver, in which a high-fat diet may have aggravated its toxicity.

References

Wild S, Roglic G, Green A, Sicree R, King H . Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care. 2004; 27(5):1047-53. DOI: 10.2337/diacare.27.5.1047. View

Bagchi D, Bagchi M, Hassoun E, Stohs S . In vitro and in vivo generation of reactive oxygen species, DNA damage and lactate dehydrogenase leakage by selected pesticides. Toxicology. 1995; 104(1-3):129-40. DOI: 10.1016/0300-483x(95)03156-a. View

Leonel Javeres M, Raza S, Judith N, Anwar F, Habib R, Batool S . Mixture of Organophosphates Chronic Exposure and Pancreatic Dysregulations in Two Different Population Samples. Front Public Health. 2020; 8:534902. PMC: 7655777. DOI: 10.3389/fpubh.2020.534902. View

Heeren J, Scheja L . Metabolic-associated fatty liver disease and lipoprotein metabolism. Mol Metab. 2021; 50:101238. PMC: 8324684. DOI: 10.1016/j.molmet.2021.101238. View

Salek-Maghsoudi A, Hassani S, Momtaz S, Shadboorestan A, Ganjali M, Ghahremani M . Biochemical and molecular evidence on the role of vaspin in early detection of the insulin resistance in a rat model of high-fat diet and use of diazinon. Toxicology. 2018; 411:1-14. DOI: 10.1016/j.tox.2018.10.014. View

Schreinemachers D . Mortality from ischemic heart disease and diabetes mellitus (type 2) in four U.S. wheat-producing states: a hypothesis-generating study. Environ Health Perspect. 2006; 114(2):186-93. PMC: 1367830. DOI: 10.1289/ehp.8352. View

Adedeji T, Jeje S, Omayone T, Agbonifo W . Oxidative stress and inflammatory response to high dietary fat and carbonated soda intake in male and female Wistar rats. Nutrition. 2022; 103-104:111800. DOI: 10.1016/j.nut.2022.111800. View

Itou da Silva F, Bizerra P, Mito M, Constantin R, Klosowski E, de Souza B . The metabolic and toxic acute effects of phloretin in the rat liver. Chem Biol Interact. 2022; 364:110054. DOI: 10.1016/j.cbi.2022.110054. View

Guo X, Wang H, Song Q, Li N, Liang Q, Su W . Association between exposure to organophosphorus pesticides and the risk of diabetes among US Adults: Cross-sectional findings from the National Health and Nutrition Examination Survey. Chemosphere. 2022; 301:134471. DOI: 10.1016/j.chemosphere.2022.134471. View

10.

Yang J, Lu Y, Bai Y, Cheng Z . Sex-specific and dose-response relationships of urinary cobalt and molybdenum levels with glucose levels and insulin resistance in U.S. adults. J Environ Sci (China). 2022; 124:42-49. DOI: 10.1016/j.jes.2021.10.023. View

11.

Wang X, Shen M, Zhou J, Jin Y . Chlorpyrifos disturbs hepatic metabolism associated with oxidative stress and gut microbiota dysbiosis in adult zebrafish. Comp Biochem Physiol C Toxicol Pharmacol. 2018; 216:19-28. DOI: 10.1016/j.cbpc.2018.11.010. View

12.

Acker C, Nogueira C . Chlorpyrifos acute exposure induces hyperglycemia and hyperlipidemia in rats. Chemosphere. 2012; 89(5):602-8. DOI: 10.1016/j.chemosphere.2012.05.059. View

13.

Picard A, Berney X, Castillo-Armengol J, Tarussio D, Jan M, Sanchez-Archidona A . Hypothalamic Irak4 is a genetically controlled regulator of hypoglycemia-induced glucagon secretion. Mol Metab. 2022; 61:101479. PMC: 9046887. DOI: 10.1016/j.molmet.2022.101479. View

14.

Ismail A, Hendy O, Abdel Rasoul G, Olson J, Bonner M, Rohlman D . Acute and Cumulative Effects of Repeated Exposure to Chlorpyrifos on the Liver and Kidney Function among Egyptian Adolescents. Toxics. 2021; 9(6). PMC: 8230541. DOI: 10.3390/toxics9060137. View

15.

Li Z, Pan Y, Zhang Y, Qin J, Lei X . Dietary experiences after bariatric surgery in patients with obesity: A qualitative systematic review. Obes Surg. 2022; 32(6):2023-2034. DOI: 10.1007/s11695-022-06018-8. View

16.

Banerjee B, Seth V, Ahmed R . Pesticide-induced oxidative stress: perspectives and trends. Rev Environ Health. 2001; 16(1):1-40. DOI: 10.1515/reveh.2001.16.1.1. View

17.

Osaili T, Al Sallagi M, Dhanasekaran D, Bani Odeh W, Al Ali H, Al Ali A . Pesticide residues in fresh fruits imported into the United Arab Emirates. Heliyon. 2022; 8(12):e11946. PMC: 9719009. DOI: 10.1016/j.heliyon.2022.e11946. View

18.

Leonel Javeres M, Habib R, Laure N, Shah S, Valis M, Kuca K . Chronic Exposure to Organophosphates Pesticides and Risk of Metabolic Disorder in Cohort from Pakistan and Cameroon. Int J Environ Res Public Health. 2021; 18(5). PMC: 7967685. DOI: 10.3390/ijerph18052310. View

19.

Chen Y, Pai M, Chen Y, Hou Y . Dietary exposure to chlorpyrifos affects systemic and hepatic immune-cell phenotypes in diabetic mice. Toxicology. 2021; 452:152698. DOI: 10.1016/j.tox.2021.152698. View

20.

Li J, Pang G, Ren F, Fang B . Chlorpyrifos-induced reproductive toxicity in rats could be partly relieved under high-fat diet. Chemosphere. 2019; 229:94-102. DOI: 10.1016/j.chemosphere.2019.05.020. View