Global Switch from DICER-dependent MicroRNA to DICER-independent SnoRNA-derived RNA Biogenesis in Malignancy

Overview

Journal MicroPubl Biol

Specialty Biology

Date 2023 Feb 23

PMID 36818311

Authors

Noel L Godang

Jeffrey D DeMeis

Dominika Houserova

Neil Y Chaudhary

Carly J Salter

Yaguang Xi

Oliver G McDonald

Glen M Borchert

Affiliations

Soon will be listed here.

Abstract

SnoRNAs are frequently processed into snoRNA-derived RNAs (sdRNAs) that function much like traditional microRNAs (miRNAs). That said, our analyses suggest a global switch from DICER-dependent (predominately miRNA) to DICER-independent (predominately sdRNA) biogenesis/gene regulation in colon cancer. Whereas the expressions of 259 of 288 appreciably expressed miRNAs are significantly decreased (avg. 6.4% of WT) in human colon cancer DICER-KOs, 95 of 103 sdRNAs are conversely, significantly increased (avg. 679.3%) in DICER-KOs as compared to WT. As many diseases are characterized by DICER deficiency, this putative global switch to DICER-independent sdRNA regulations may contribute to an array of human diseases.

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