Is Vitamin D Deficiency Influenced by Obesity During the First 5 years of Life? A Cross-sectional Multicenter Study

Overview

Journal Food Sci Nutr

Specialty Biotechnology

Date 2023 Feb 15

PMID 36789058

Authors

Yan Zhao

Rui Qin

Hong Hong

Heyu Lv

Kan Ye

Yarong Wei

Wen Zheng

Hongxia Qi

Yufei Ni

Li Zhang

Guoqiang Yang

Guoqin Liu

Aiping Wu

Affiliations

Soon will be listed here.

Abstract

Evidence on the association of 25-hydroxyvitamin D (25[OH]D) and obesity during the first 5 years of life is limited in China. The objective of this study was to examine the associations between weight, weight for age score (ZWAZ), weight for length/height score (ZWHZ), and body mass index for age score (ZBMI) and 25(OH)D. This was a large population-based cross-sectional multicenter study in which the children aged 0-5 years were recruited from 12 children's healthcare centers by a stratified cluster random-sampling method in 10 cities of the Jiangsu province, China. The 25(OH)D concentration was determined by ELISA. A total of 5289 children were investigated. For 0-71 months children with obesity and nonobesity, the prevalence of vitamin D deficiency was 36.0% and 29.8%, and the 25(OH)D level was 59.8 and 64.0 nmol/L, respectively, and there were all significant difference. Compared with children with nonobesity, children with obesity had higher risk of vitamin D deficiency (OR [95% CI]: 1.33 [1.02, 1.72], < .05), and had lower 25(OH)D level (β = -3.84, 95% CI = -7.58, -0.09, < .05). The results for children aged 24-71 months were similar to those for children aged 0-71 months. However, no significant difference was observed in children aged 0-23 months. Vitamin D deficiency was observed in children with greater adiposity during the first 5 years of life. However, the results mainly came from those in the age group of 2 to 5 years instead of the first 2 years in their lives.

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