Advances in Brain Metastasis Models

Overview

Journal Brain Tumor Res Treat

Date 2023 Feb 10

PMID 36762804

Authors

Jung Eun Lee

Seung Ho Yang

Affiliations

Soon will be listed here.

Abstract

To obtain achievements in addressing the clinical challenges of brain metastasis, we need a clear understanding of its biological mechanisms. Brain metastasis research is challenged by many practical scientific barriers. Depending on the purpose of the study, experimental brain metastasis models can be used. It is now possible to re-create the architecture and physiology of human organs. Human organoids provide unique opportunities for the study of human disease and complement animal models. The translation of experimental findings to clinical application has several barriers in the development of treatment for brain metastasis. A variety of models have provided significant contributions to the knowledge of brain metastasis pathology and remain pivotal tools for examining novel therapeutic strategies.

Citing Articles

IMMUNE AND MOLECULAR CORRELATES OF RESPONSE TO IMMUNOTHERAPY REVEALED BY BRAIN-METASTATIC MELANOMA MODELS.

Daugherty-Lopes A, Perez-Guijarro E, Gopalan V, Rappaport J, Chen Q, Huang A bioRxiv. 2024; .

PMID: 39372744 PMC: 11451731. DOI: 10.1101/2024.08.26.609785.

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