Prospective Clinical Study of Retinal Microvascular Alteration After ICL Implantation

Overview

Journal Front Cell Dev Biol

Specialty Cell Biology

Date 2023 Feb 6

PMID 36743408

Authors

Chuhao Tang

Yu Zhang

Tong Sun

Jianyang Xie

Yiyun Liu

Rongjun Liu

Zhengze Sun

Hong Qi

Affiliations

Soon will be listed here.

Abstract

To evaluate the retinal microvascular alteration after implantable collamer lens (ICL) implantation in moderate to high myopia patients using quantitative optical coherence tomography angiography (OCTA). This prospective cohort study included 50 eyes of 25 patients with preoperative spherical equivalent ≥ -3.00 D. Patients underwent bilateral ICL implantation at the Department of Ophthalmology, Peking University Third Hospital, from November 2018 to July 2019. OCTA was used to image the superficial and deep retinal capillary plexuses before ICL implantation surgery and at 3 months follow-up. There was no significant difference in the microvascular density within each annular zone and all quadrantal zones of the superficial and deep layers found in myopia patients before and after ICL surgery. Levels of microvascular density in retinal capillary plexuses were stable, as detected by the OCTA, showing the high security of ICL implantation, which would not leave adverse effects on retinal microvasculature in myopia patients.

Citing Articles

Evaluation of retinal and choroidal microvascular alteration after ICL V4c implantation based on OCTA.

Zhao B, Zhang H, Fang X, Wang Y, Chai J, Li Y BMC Ophthalmol. 2024; 24(1):487.

PMID: 39506746 PMC: 11539432. DOI: 10.1186/s12886-024-03752-8.

References

Wylegala A . Principles of OCTA and Applications in Clinical Neurology. Curr Neurol Neurosci Rep. 2018; 18(12):96. PMC: 6209039. DOI: 10.1007/s11910-018-0911-x. View

Liu J, Liu Q, Yu H, Xia Y, Zhang H, Geng C . Microvascular Changes in Macular Area After Phacoemulsification and Its Influencing Factors Assessed by Optical Coherence Tomography Angiography. Ther Clin Risk Manag. 2021; 17:405-414. PMC: 8131067. DOI: 10.2147/TCRM.S309679. View

Sun Z, Yang D, Tang Z, Ng D, Cheung C . Optical coherence tomography angiography in diabetic retinopathy: an updated review. Eye (Lond). 2020; 35(1):149-161. PMC: 7852654. DOI: 10.1038/s41433-020-01233-y. View

Golebiewska J, Biala-Gosek K, Czeszyk A, Hautz W . Optical coherence tomography angiography of superficial retinal vessel density and foveal avascular zone in myopic children. PLoS One. 2019; 14(7):e0219785. PMC: 6639003. DOI: 10.1371/journal.pone.0219785. View

Leng Y, Tam E, Falavarjani K, Tsui I . Effect of Age and Myopia on Retinal Microvasculature. Ophthalmic Surg Lasers Imaging Retina. 2018; 49(12):925-931. DOI: 10.3928/23258160-20181203-03. View

Makita S, Hong Y, Yamanari M, Yatagai T, Yasuno Y . Optical coherence angiography. Opt Express. 2009; 14(17):7821-40. DOI: 10.1364/oe.14.007821. View

Wang X, Zhou X . Update on Treating High Myopia With Implantable Collamer Lenses. Asia Pac J Ophthalmol (Phila). 2016; 5(6):445-449. DOI: 10.1097/APO.0000000000000235. View

Morgan I, French A, Ashby R, Guo X, Ding X, He M . The epidemics of myopia: Aetiology and prevention. Prog Retin Eye Res. 2017; 62:134-149. DOI: 10.1016/j.preteyeres.2017.09.004. View

Gao S, Jia Y, Zhang M, Su J, Liu G, Hwang T . Optical Coherence Tomography Angiography. Invest Ophthalmol Vis Sci. 2016; 57(9):OCT27-36. PMC: 4968919. DOI: 10.1167/iovs.15-19043. View

10.

Jiang Y, Lou S, Li Y, Chen Y, Lu T . High myopia and macular vascular density: an optical coherence tomography angiography study. BMC Ophthalmol. 2021; 21(1):407. PMC: 8626942. DOI: 10.1186/s12886-021-02156-2. View

11.

Al-Sheikh M, Phasukkijwatana N, Dolz-Marco R, Rahimi M, Iafe N, Freund K . Quantitative OCT Angiography of the Retinal Microvasculature and the Choriocapillaris in Myopic Eyes. Invest Ophthalmol Vis Sci. 2017; 58(4):2063-2069. DOI: 10.1167/iovs.16-21289. View

12.

Holden B, Fricke T, Wilson D, Jong M, Naidoo K, Sankaridurg P . Global Prevalence of Myopia and High Myopia and Temporal Trends from 2000 through 2050. Ophthalmology. 2016; 123(5):1036-42. DOI: 10.1016/j.ophtha.2016.01.006. View

13.

Wu P, Huang H, Yu H, Fang P, Chen C . Epidemiology of Myopia. Asia Pac J Ophthalmol (Phila). 2016; 5(6):386-393. DOI: 10.1097/APO.0000000000000236. View

14.

Pilotto E, Leonardi F, Stefanon G, Longhin E, Torresin T, Deganello D . Early retinal and choroidal OCT and OCT angiography signs of inflammation after uncomplicated cataract surgery. Br J Ophthalmol. 2018; 103(7):1001-1007. DOI: 10.1136/bjophthalmol-2018-312461. View

15.

Chen P, Cai X, Xu L, Zhang J, Yang Y, Gao Q . Assessing oxygen saturation in retinal vessels in high myopia patients pre- and post-implantable collamer lens implantation surgery. Acta Ophthalmol. 2017; 95(6):576-582. DOI: 10.1111/aos.13368. View

16.

Foster P, Jiang Y . Epidemiology of myopia. Eye (Lond). 2014; 28(2):202-8. PMC: 3930282. DOI: 10.1038/eye.2013.280. View

17.

Assetto V, Benedetti S, Pesando P . Collamer intraocular contact lens to correct high myopia. J Cataract Refract Surg. 1996; 22(5):551-6. DOI: 10.1016/s0886-3350(96)80007-1. View

18.

Grudzinska E, Modrzejewska M . Modern Diagnostic Techniques for the Assessment of Ocular Blood Flow in Myopia: Current State of Knowledge. J Ophthalmol. 2018; 2018:4694789. PMC: 5828053. DOI: 10.1155/2018/4694789. View

19.

Sanders D, Doney K, Poco M . United States Food and Drug Administration clinical trial of the Implantable Collamer Lens (ICL) for moderate to high myopia: three-year follow-up. Ophthalmology. 2004; 111(9):1683-92. DOI: 10.1016/j.ophtha.2004.03.026. View

20.

Zhang Q, Lee C, Chao J, Chen C, Zhang T, Sharma U . Wide-field optical coherence tomography based microangiography for retinal imaging. Sci Rep. 2016; 6:22017. PMC: 4766473. DOI: 10.1038/srep22017. View