Microvascular Changes in Macular Area After Phacoemulsification and Its Influencing Factors Assessed by Optical Coherence Tomography Angiography

Overview

Journal Ther Clin Risk Manag

Publisher Dove Medical Press

Date 2021 May 21

PMID 34017174

Citations 6

Authors

Jun Liu

Qiang Liu

Hua Yu

Ye Xia

Hui Zhang

Chao Geng

Lihong Dong

Affiliations

Soon will be listed here.

Abstract

Objective: To investigate macular vascular changes and underlying influencing factors using optical coherence tomography angiography (OCTA) after phacoemulsification in patients with cataracts.

Methods: Patients diagnosed with cataracts at the First Affiliated Hospital of Anhui Medical University from March to September 2019 were included. The macular retinal thickness, the microvascular density in the foveal, parafoveal, and perifoveal area, and the area of the foveal avascular zone (FAZ) were measured using OCTA at baseline, 1-week, 1-month, and 3-month post-operation.

Results: Forty-seven cataract patients (58 eyes) were eligible for this study. Compared with baseline thickness, the foveal, parafoveal, and perifoveal thicknesses, particularly in the inner retina, significantly increased at 1- and 3-month post-operation (P<0.05). There was a nonsignificant difference in the microvascular density of the foveal and perifoveal areas at 1-week, 1-month, and 3-month post-operation (P>0.05). At 1-month post-operation, the deep vessel density at the perifovea significantly increased (P<0.05). The FAZ area significantly diminished at 1- and 3-month post-operation compared with the baseline data (P<0.05).

Conclusion: Phacoemulsification offers a satisfactory efficacy response, with an increased macular thickness, reduced FAZ area, and nonsignificant changes in the microvascular density at the perifovea after surgery.

Citing Articles

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Tang C, Zhang Y, Sun T, Xie J, Liu Y, Liu R Front Cell Dev Biol. 2023; 11:1115822.

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Application of the Active-Fluidics System in Phacoemulsification: A Review.

Luo Y, Xu G, Li H, Ma T, Ye Z, Li Z J Clin Med. 2023; 12(2).

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Long-Term Functional Hyperemia after Uncomplicated Phacoemulsification: Benefits beyond Restoring Vision.

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A prospective randomized clinical trial of active-fluidics versus gravity-fluidics system in phacoemulsification for age-related cataract (AGSPC).

Luo Y, Li H, Chen W, Gao Y, Ma T, Ye Z Ann Med. 2022; 54(1):1977-1987.

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Decreased Macular Retinal Thickness in Patients With Pterygium.

Wang F, Liu L, Liang R, Zhang L, Shu H, Liao X Front Neurol. 2022; 13:881190.

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References

Artigas J, Felipe A, Navea A, Fandino A, Artigas C . Spectral transmission of the human crystalline lens in adult and elderly persons: color and total transmission of visible light. Invest Ophthalmol Vis Sci. 2012; 53(7):4076-84. DOI: 10.1167/iovs.12-9471. View

Hilton E, Hosking S, Gherghel D, Embleton S, Cunliffe I . Beneficial effects of small-incision cataract surgery in patients demonstrating reduced ocular blood flow characteristics. Eye (Lond). 2004; 19(6):670-5. DOI: 10.1038/sj.eye.6701620. View

Bhagat N, Grigorian R, Tutela A, Zarbin M . Diabetic macular edema: pathogenesis and treatment. Surv Ophthalmol. 2009; 54(1):1-32. DOI: 10.1016/j.survophthal.2008.10.001. View

Xu H, Chen M, Forrester J, Lois N . Cataract surgery induces retinal pro-inflammatory gene expression and protein secretion. Invest Ophthalmol Vis Sci. 2010; 52(1):249-55. DOI: 10.1167/iovs.10-6001. View

Ferrari T, Cavallo M, Durante G, Mininno L, Cardascia N . Macular edema induced by phacoemulsification. Doc Ophthalmol. 2000; 97(3-4):325-7. DOI: 10.1023/a:1002142307952. View

Matsunaga D, Yi J, Olmos de Koo L, Ameri H, Puliafito C, Kashani A . Optical Coherence Tomography Angiography of Diabetic Retinopathy in Human Subjects. Ophthalmic Surg Lasers Imaging Retina. 2015; 46(8):796-805. DOI: 10.3928/23258160-20150909-03. View

Libre P . Intraoperative light toxicity: a possible explanation for the association between cataract surgery and age-related macular degeneration. Am J Ophthalmol. 2003; 136(5):961. DOI: 10.1016/s0002-9394(03)00906-1. View

Cohen S, Miere A, Nghiem-Buffet S, Fajnkuchen F, Souied E, Mrejen S . Clinical applications of optical coherence tomography angiography: What we have learnt in the first 3 years. Eur J Ophthalmol. 2018; 28(5):491-502. DOI: 10.1177/1120672117753704. View

Sourdille P, Santiago P . Optical coherence tomography of macular thickness after cataract surgery. J Cataract Refract Surg. 1999; 25(2):256-61. DOI: 10.1016/s0886-3350(99)80136-9. View

10.

Wang X, Jia Y, Spain R, Potsaid B, Liu J, Baumann B . Optical coherence tomography angiography of optic nerve head and parafovea in multiple sclerosis. Br J Ophthalmol. 2014; 98(10):1368-73. PMC: 4598177. DOI: 10.1136/bjophthalmol-2013-304547. View

11.

Hussein K, Choksi K, Akeel S, Ahmad S, Megyerdi S, El-Sherbiny M . Bone morphogenetic protein 2: a potential new player in the pathogenesis of diabetic retinopathy. Exp Eye Res. 2014; 125:79-88. PMC: 4122600. DOI: 10.1016/j.exer.2014.05.012. View

12.

Chen Z, Song F, Sun L, Zhao C, Gao N, Liu P . Corneal integrity and thickness of central fovea after phacoemulsification surgery in diabetic and nondiabetic cataract patients. Arch Med Sci. 2018; 14(4):818-825. PMC: 6040132. DOI: 10.5114/aoms.2016.64036. View

13.

Wang X, Zhou L, Huang Y . [Clinical significance of accumulated energy complex parameter in phacoemulsification]. Zhonghua Yan Ke Za Zhi. 2002; 38(10):610-3. View

14.

Desapriya E, Subzwari S, Scime-Beltrano G, Samayawardhena L, Pike I . Vision improvement and reduction in falls after expedited cataract surgery Systematic review and metaanalysis. J Cataract Refract Surg. 2010; 36(1):13-9. DOI: 10.1016/j.jcrs.2009.07.032. View

15.

Zhao Z, Wen W, Jiang C, Lu Y . Changes in macular vasculature after uncomplicated phacoemulsification surgery: Optical coherence tomography angiography study. J Cataract Refract Surg. 2018; 44(4):453-458. DOI: 10.1016/j.jcrs.2018.02.014. View

16.

Yu S, Frueh B, Steinmair D, Ebneter A, Wolf S, Zinkernagel M . Cataract significantly influences quantitative measurements on swept-source optical coherence tomography angiography imaging. PLoS One. 2018; 13(10):e0204501. PMC: 6168135. DOI: 10.1371/journal.pone.0204501. View

17.

Weigert G, Findl O, Luksch A, Rainer G, Kiss B, Vass C . Effects of moderate changes in intraocular pressure on ocular hemodynamics in patients with primary open-angle glaucoma and healthy controls. Ophthalmology. 2005; 112(8):1337-42. DOI: 10.1016/j.ophtha.2005.03.016. View

18.

Cheng B, Liu Y, Liu X, Ge J, Ling Y, Zheng X . [Macular image changes of optical coherence tomography after phacoemulsification]. Zhonghua Yan Ke Za Zhi. 2002; 38(5):265-7. View