Designing Animal-friendly Behavioral Tests for Neuroscience Research: The Importance of an Ethological Approach

Overview

Journal Front Behav Neurosci

Specialty Psychology

Date 2023 Jan 27

PMID 36703720

Authors

Raffaele dIsa

Robert Gerlai

Affiliations

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References

Gerlai R, Clayton N . Analysing hippocampal function in transgenic mice: an ethological perspective. Trends Neurosci. 1999; 22(2):47-51. DOI: 10.1016/s0166-2236(98)01346-0. View

Deacon R . Assessing hoarding in mice. Nat Protoc. 2007; 1(6):2828-30. DOI: 10.1038/nprot.2006.171. View

Puscian A, Leski S, Kasprowicz G, Winiarski M, Borowska J, Nikolaev T . Eco-HAB as a fully automated and ecologically relevant assessment of social impairments in mouse models of autism. Elife. 2016; 5. PMC: 5092044. DOI: 10.7554/eLife.19532. View

Chidiac C, Xue Y, Muniz Moreno M, Rasheed A, Lorentz R, Birling M . The Human SCN10A Point Mutation Established in Mice Impacts on Mechanical, Heat, and Cool Sensitivity. Front Pharmacol. 2021; 12:780132. PMC: 8671994. DOI: 10.3389/fphar.2021.780132. View

Heinla I, Chu X, Agmo A, Snoeren E . Rat ultrasonic vocalizations and novelty-induced social and non-social investigation behavior in a seminatural environment. Physiol Behav. 2021; 237:113450. DOI: 10.1016/j.physbeh.2021.113450. View

Gerlai R . From Genes to Behavior: The Question of Evolutionary Conservation and the Role of Ethology in the Analysis of the Zebrafish. Front Neuroanat. 2021; 15:809967. PMC: 8675880. DOI: 10.3389/fnana.2021.809967. View

Poulos A, Mehta N, Lu B, Amir D, Livingston B, Santarelli A . Conditioning- and time-dependent increases in context fear and generalization. Learn Mem. 2016; 23(7):379-85. PMC: 4918784. DOI: 10.1101/lm.041400.115. View

Crowley S, Kataoka K, Itaka K . Combined CatWalk Index: an improved method to measure mouse motor function using the automated gait analysis system. BMC Res Notes. 2018; 11(1):263. PMC: 5924449. DOI: 10.1186/s13104-018-3374-x. View

Nomoto K, Ikumi M, Otsuka M, Asaba A, Kato M, Koshida N . Female mice exhibit both sexual and social partner preferences for vocalizing males. Integr Zool. 2018; 13(6):735-744. DOI: 10.1111/1749-4877.12357. View

10.

Ruzza C, Asth L, Guerrini R, Trapella C, Gavioli E . Neuropeptide S reduces mouse aggressiveness in the resident/intruder test through selective activation of the neuropeptide S receptor. Neuropharmacology. 2015; 97:1-6. DOI: 10.1016/j.neuropharm.2015.05.002. View

11.

Frisch C, Hasenohrl R, Mattern C, Hacker R, Huston J . Blockade of lithium chloride-induced conditioned place aversion as a test for antiemetic agents: comparison of metoclopramide with combined extracts of Zingiber officinale and Ginkgo biloba. Pharmacol Biochem Behav. 1995; 52(2):321-7. DOI: 10.1016/0091-3057(95)00073-6. View

12.

Otsuka S . Predator Odor-induced Freezing Test for Mice. Bio Protoc. 2021; 7(17):e2534. PMC: 8413536. DOI: 10.21769/BioProtoc.2534. View

13.

Richter C . On the phenomenon of sudden death in animals and man. Psychosom Med. 1957; 19(3):191-8. DOI: 10.1097/00006842-195705000-00004. View

14.

Montag-Sallaz M, Montag D . Severe cognitive and motor coordination deficits in tenascin-R-deficient mice. Genes Brain Behav. 2003; 2(1):20-31. DOI: 10.1034/j.1601-183x.2003.00003.x. View

15.

Mingrone A, Kaffman A, Kaffman A . The Promise of Automated Home-Cage Monitoring in Improving Translational Utility of Psychiatric Research in Rodents. Front Neurosci. 2021; 14:618593. PMC: 7773806. DOI: 10.3389/fnins.2020.618593. View

16.

Yang X, Liu Q, Zhong J, Song R, Zhang L, Wang L . A simple threat-detection strategy in mice. BMC Biol. 2020; 18(1):93. PMC: 7388474. DOI: 10.1186/s12915-020-00825-0. View

17.

Le Moene O, Hernandez-Arteaga E, Chu X, Agmo A . Rapid changes in sociosexual behaviors around transition to and from behavioral estrus, in female rats housed in a seminatural environment. Behav Processes. 2020; 174:104101. DOI: 10.1016/j.beproc.2020.104101. View

18.

Reppucci C, Veenema A . The social versus food preference test: A behavioral paradigm for studying competing motivated behaviors in rodents. MethodsX. 2020; 7:101119. PMC: 7666348. DOI: 10.1016/j.mex.2020.101119. View

19.

Guarraci F, Frohardt R . "What a Girl Wants": What Can We Learn From Animal Models of Female Sexual Motivation?. Front Behav Neurosci. 2019; 13:216. PMC: 6763560. DOI: 10.3389/fnbeh.2019.00216. View

20.

Deacon R . Burrowing: a sensitive behavioural assay, tested in five species of laboratory rodents. Behav Brain Res. 2009; 200(1):128-33. DOI: 10.1016/j.bbr.2009.01.007. View