Organoid Intelligence for Developmental Neurotoxicity Testing

Overview

Journal Front Cell Neurosci

Specialty Cell Biology

Date 2024 Oct 23

PMID 39440004

Authors

Dowlette-Mary Alam El Din

Jeongwon Shin

Alexandra Lysinger

Matthew J Roos

Erik C Johnson

Timothy J Shafer

Thomas Hartung

Lena Smirnova

Affiliations

Soon will be listed here.

Abstract

The increasing prevalence of neurodevelopmental disorders has highlighted the need for improved testing methods to determine developmental neurotoxicity (DNT) hazard for thousands of chemicals. This paper proposes the integration of organoid intelligence (OI); leveraging brain organoids to study neuroplasticity into the DNT testing paradigm. OI brings a new approach to measure the impacts of xenobiotics on plasticity mechanisms - a critical biological process that is not adequately covered in current DNT assays. Finally, the integration of artificial intelligence (AI) techniques will further facilitate the analysis of complex brain organoid data to study these plasticity mechanisms.

Citing Articles

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