Structural Elucidation of a Novel Arabinogalactan LFP-80-W1 from Lycii Fructus with Potential Immunostimulatory Activity

Overview

Journal Front Nutr

Specialty Nutritional Sciences

Date 2023 Jan 23

PMID 36687689

Authors

Xiaofei Liang

Mengqiu Liu

Sheng Guo

Fang Zhang

Wanchen Cui

Fei Zeng

Mingming Xu

Dawei Qian

Jinao Duan

Affiliations

Soon will be listed here.

Abstract

Polysaccharides are the most important effective components of Lycii fructus, which has a variety of biological activities and broad application prospects in the fields of medicine and food. In this study, we reported a novel arabinogalactan LFP-80-W1 with potential immunostimulatory activity. LFP-80-W1 was a continuous symmetrical single-peak with an average molecular weight of 4.58 × 10 Da and was mainly composed of arabinose and galactose. Oligosaccharide sequencing analyses and NMR data showed that the LFP-80-W1 domain consists of a repeated 1,6-linked β-Gal main chain with branches arabinoglycan and arabinogalactan at position C-3. Importantly, we found that LFP-80-W1 could activate the MAPK pathway and promote the release of NO, IL-6, and TNF-α cytokines . Therefore, our findings suggest that the homogeneous arabinogalactan from Lycii fructus, can be used as a natural immunomodulator.

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