Effects of Polysaccharides in Lycium Barbarum Berries from Different Regions of China on Macrophages Function and Their Correlation to the Glycosidic Linkages

Practical Application: The results showed that immunomodulation effects of polysaccharides in L. barbarum berries (LBPs) from different regions are similar, but different in degree, this might be caused by their different content of bioactive polysaccharides. Moreover, an enzymatic digestion method was used to investigate the structure-bioactivity relationship of polysaccharides from LBPs. The result indicated that α-1,4-d-galactosiduronic and α-1,5-arabinosidic linkages, especially the former one was significantly affect the immunomodulation effects of LBPs. The results were beneficial to the improvement of pharmacological activity-based quality control of LBPs and future development of related unique functional and health products.