ACE Inhibitory Peptides Derived from Muscovy Duck () Plasma

Overview

Journal Foods

Specialty Biotechnology

Date 2023 Jan 8

PMID 36613266

Authors

Zongshuai Zhu

Haoyu Guo

Yan Xu

Anthony Pius Bassey

Ahtisham Ali

Ming Huang

Jichao Huang

Affiliations

Soon will be listed here.

Abstract

In this study, angiotensin-converting enzyme inhibitory peptides (ACE-IPs) derived from Muscovy duck () plasma hydrolysate (MDPH) were investigated. According to the general research protocol for bioactive peptides, the crude ACE-IPs of Muscovy duck plasma were separated and purified by ultrafiltration, gel chromatography and reversed-phase high-performance liquid chromatography (RP-HPLC). Then the components with the highest ACE inhibition potential were selected for identification. Finally, the inhibition mechanism was explored by molecular docking and in silico simulated digestion. A total of 121 peptides was detected, and five were screened for synthesis verification and molecular docking. The peptide VALSSLRP revealed high ACE inhibitory activity (91.67 ± 0.73%) because this peptide bound tightly to the S1' pocket and formed 3 hydrogen bonds. Meaningfully, this work provides some new information about the generation of ACE-IPs derived from duck blood plasma.

Citing Articles

Screening of Potential Angiotensin-Converting Enzyme-Inhibitory Peptides in Squid () Skin Hydrolysates: Preliminary Study of Its Mechanism of Inhibition.

Li M, Liang Q, Zhang Y, Jiang X, Gu Y, Song X Mar Drugs. 2025; 23(2).

PMID: 39997205 PMC: 11857160. DOI: 10.3390/md23020081.

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