A Novel Cortisol Immunosensor Based on a Hafnium Oxide/Silicon Structure for Heart Failure Diagnosis

Overview

Journal Micromachines (Basel)

Publisher MDPI

Date 2022 Dec 23

PMID 36557534

Authors

Hamdi Ben Halima

Nadia Zine

Joan Bausells

Nicole Jaffrezic-Renault

Abdelhamid Errachid

Affiliations

Soon will be listed here.

Abstract

Assessing cortisol levels in human bodies has become essential to diagnose heart failure (HF). In this work, we propose a salivary cortisol detection strategy as part of an easily integrable lab-on-a-chip for detection of HF biomarkers. Our developed capacitive immunosensor based on hafnium oxide (HfO2)/silicon structure showed good linearity between increasing cortisol concentration and the charge-transfer resistance/capacitance. Moreover, the developed biosensor was demonstrated to be highly selective toward cortisol compared to other HF biomarkers such as tumor necrosis factor (TNF-α) and N-terminal pro-brain natriuretic peptide (NT-proBNP). The precision of our developed biosensor was evaluated, and the difference between the determined cortisol concentration in saliva and its expected one is <18%.

Citing Articles

Salivary Cortisol Detection with a Fully Inkjet-Printed Paper-Based Electrochemical Sensor.

Zea M, Ben Halima H, Villa R, Nemeir I, Zine N, Errachid A Micromachines (Basel). 2024; 15(10).

PMID: 39459126 PMC: 11509315. DOI: 10.3390/mi15101252.

An ImmunoFET Coupled with an Immunomagnetic Preconcentration Technique for the Sensitive EIS Detection of HF Biomarkers.

Ben Halima H, Zine N, Nemeir I, Pfeiffer N, Heuberger A, Bausells J Micromachines (Basel). 2024; 15(3).

PMID: 38542544 PMC: 10972101. DOI: 10.3390/mi15030296.

Cortisol Monitoring Devices toward Implementation for Clinically Relevant Biosensing In Vivo.

Kusov P, Kotelevtsev Y, Drachev V Molecules. 2023; 28(5).

PMID: 36903600 PMC: 10005364. DOI: 10.3390/molecules28052353.

Selective Antibody-Free Sensing Membranes for Picogram Tetracycline Detection.

Ben Halima H, Baraket A, Vinas C, Zine N, Bausells J, Jaffrezic-Renault N Biosensors (Basel). 2023; 13(1).

PMID: 36671906 PMC: 9855611. DOI: 10.3390/bios13010071.

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