Cathepsins Trigger Cell Death and Regulate Radioresistance in Glioblastoma

Overview

Journal Cells

Publisher MDPI

Specialties Biochemistry
Biophysics
Cell Biology
Molecular Biology

Date 2022 Dec 23

PMID 36552871

Authors

Xiaofeng Ding

Chen Zhang

Huajian Chen

MingHua Ren

Xiaodong Liu

Affiliations

Soon will be listed here.

Abstract

Treatment of glioblastoma (GBM) remains very challenging, and it is particularly important to find sensitive and specific molecular targets. In this work, we reveal the relationship between the expression of cathepsins and radioresistance in GBM. We analyzed cathepsins (cathepsin B, cathepsin D, cathepsin L, and cathepsin Z/X), which are highly associated with the radioresistance of GBM by regulating different types of cell death. Cathepsins could be potential targets for GBM treatment.

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