Pharmacological Activity of Quercetin: An Updated Review

Overview

Journal Evid Based Complement Alternat Med

Specialty Rehabilitation Medicine

Date 2022 Dec 12

PMID 36506811

Authors

Guanzhen Wang

Yuanhui Wang

Liangliang Yao

Wei Gu

Shengchao Zhao

Ziyi Shen

Zihan Lin

Wei Liu

Tingdong Yan

Affiliations

Soon will be listed here.

Abstract

Quercetin, a natural flavonoid compound with a widespread occurrence throughout the plant kingdom, exhibits a variety of pharmacological activities. Because of the wide spectrum of health-promoting effects, quercetin has attracted much attention of dietitians and medicinal chemists. An updated review of the literature on quercetin was performed using PubMed, Embase, and Science Direct databases. This article presents an overview of recent developments in pharmacological activities of quercetin including anti-SARS-CoV-2, antioxidant, anticancer, antiaging, antiviral, and anti-inflammatory activities as well as the mechanism of actions involved. The biological activities of quercetin were evaluated both and , involving a number of cell lines and animal models, but metabolic mechanisms of quercetin in the human body are not clear. Therefore, further large sample clinical studies are needed to determine the appropriate dosage and form of quercetin for the treatment of the disease.

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References

Wu L, Li J, Liu T, Li S, Feng J, Yu Q . Quercetin shows anti-tumor effect in hepatocellular carcinoma LM3 cells by abrogating JAK2/STAT3 signaling pathway. Cancer Med. 2019; 8(10):4806-4820. PMC: 6712453. DOI: 10.1002/cam4.2388. View

Yang D, Wang T, Long M, Li P . Quercetin: Its Main Pharmacological Activity and Potential Application in Clinical Medicine. Oxid Med Cell Longev. 2021; 2020:8825387. PMC: 7790550. DOI: 10.1155/2020/8825387. View

Karimi A, Naeini F, Asghari Azar V, Hasanzadeh M, Ostadrahimi A, Niazkar H . A comprehensive systematic review of the therapeutic effects and mechanisms of action of quercetin in sepsis. Phytomedicine. 2021; 86:153567. DOI: 10.1016/j.phymed.2021.153567. View

Hermankova E, Zatloukalova M, Biler M, Sokolova R, Bancirova M, Tzakos A . Redox properties of individual quercetin moieties. Free Radic Biol Med. 2019; 143:240-251. DOI: 10.1016/j.freeradbiomed.2019.08.001. View

Pham T, Stempel S, Shields M, Spaulding C, Kumar K, Bentrem D . Quercetin Enhances the Anti-Tumor Effects of BET Inhibitors by Suppressing hnRNPA1. Int J Mol Sci. 2019; 20(17). PMC: 6747365. DOI: 10.3390/ijms20174293. View

Passos J, Saretzki G, von Zglinicki T . DNA damage in telomeres and mitochondria during cellular senescence: is there a connection?. Nucleic Acids Res. 2007; 35(22):7505-13. PMC: 2190715. DOI: 10.1093/nar/gkm893. View

Shakerian E, Afarin R, Akbari R, Mohammadtaghvaei N . Effect of Quercetin on the fructose-activated human hepatic stellate cells, LX-2, an in-vitro study. Mol Biol Rep. 2022; 49(4):2839-2845. DOI: 10.1007/s11033-021-07097-z. View

Sunoqrot S, Al-Debsi T, Al-Shalabi E, Ibrahim L, Faruqu F, Walters A . Bioinspired Polymerization of Quercetin to Produce a Curcumin-Loaded Nanomedicine with Potent Cytotoxicity and Cancer-Targeting Potential in Vivo. ACS Biomater Sci Eng. 2021; 5(11):6036-6045. DOI: 10.1021/acsbiomaterials.9b01240. View

Kim C, Kim J, Song Y . Antiviral Activities of Quercetin and Isoquercitrin Against Human Herpesviruses. Molecules. 2020; 25(10). PMC: 7287991. DOI: 10.3390/molecules25102379. View

10.

Erdogan S, Turkekul K, Dibirdik I, Doganlar O, Doganlar Z, Bilir A . Midkine downregulation increases the efficacy of quercetin on prostate cancer stem cell survival and migration through PI3K/AKT and MAPK/ERK pathway. Biomed Pharmacother. 2018; 107:793-805. DOI: 10.1016/j.biopha.2018.08.061. View

11.

Sturza A, Pavel I, Ancusa S, Danciu C, Dehelean C, Duicu O . Quercetin exerts an inhibitory effect on cellular bioenergetics of the B164A5 murine melanoma cell line. Mol Cell Biochem. 2018; 447(1-2):103-109. DOI: 10.1007/s11010-018-3296-x. View

12.

Rauf A, Imran M, Ali Khan I, Ur-Rehman M, Gilani S, Mehmood Z . Anticancer potential of quercetin: A comprehensive review. Phytother Res. 2018; 32(11):2109-2130. DOI: 10.1002/ptr.6155. View

13.

Ulusoy H, Sanlier N . A minireview of quercetin: from its metabolism to possible mechanisms of its biological activities. Crit Rev Food Sci Nutr. 2019; 60(19):3290-3303. DOI: 10.1080/10408398.2019.1683810. View

14.

Hwang H, Tran D, Rebuffatti M, Li C, Knowlton A . Investigation of quercetin and hyperoside as senolytics in adult human endothelial cells. PLoS One. 2018; 13(1):e0190374. PMC: 5760026. DOI: 10.1371/journal.pone.0190374. View

15.

Lv S, Wang X, Jin S, Shen S, Wang R, Tong P . Quercetin mediates TSC2-RHEB-mTOR pathway to regulate chondrocytes autophagy in knee osteoarthritis. Gene. 2022; 820:146209. DOI: 10.1016/j.gene.2022.146209. View

16.

Hashemzaei M, Delarami Far A, Yari A, Entezari Heravi R, Tabrizian K, Taghdisi S . Anticancer and apoptosis‑inducing effects of quercetin in vitro and in vivo. Oncol Rep. 2017; 38(2):819-828. PMC: 5561933. DOI: 10.3892/or.2017.5766. View

17.

Dong B, Shi Z, Dong Y, Chen J, Wu Z, Wu W . Quercetin ameliorates oxidative stress‑induced cell apoptosis of seminal vesicles via activating Nrf2 in type 1 diabetic rats. Biomed Pharmacother. 2022; 151:113108. DOI: 10.1016/j.biopha.2022.113108. View

18.

Mi Y, Zhong L, Lu S, Hu P, Pan Y, Ma X . Quercetin promotes cutaneous wound healing in mice through Wnt/β-catenin signaling pathway. J Ethnopharmacol. 2022; 290:115066. DOI: 10.1016/j.jep.2022.115066. View

19.

Hisaka T, Sakai H, Sato T, Goto Y, Nomura Y, Fukutomi S . Quercetin Suppresses Proliferation of Liver Cancer Cell Lines . Anticancer Res. 2020; 40(8):4695-4700. DOI: 10.21873/anticanres.14469. View

20.

Soofiyani S, Hosseini K, Forouhandeh H, Ghasemnejad T, Tarhriz V, Asgharian P . Quercetin as a Novel Therapeutic Approach for Lymphoma. Oxid Med Cell Longev. 2021; 2021:3157867. PMC: 8352693. DOI: 10.1155/2021/3157867. View