Antiviral Activities of Quercetin and Isoquercitrin Against Human Herpesviruses

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2020 May 24

PMID 32443914

Citations 28

Authors

Chae Hyun Kim

Jung-Eun Kim

Yoon-Jae Song

Affiliations

Soon will be listed here.

Abstract

We previously reported that the ethyl acetate (EtOAc) fraction of a 70% ethanol extract of (ESE) inhibits varicella-zoster virus (VZV) and human cytomegalovirus (HCMV) replication in vitro. PGG (1,2,3,4,6-penta-O-galloyl-ß-D-glucose) is a major chemical constituent of the EtOAc fraction of ESE that inhibits VZV but not HCMV replication. In this study, we comprehensively screened the chemical compounds identified in the EtOAc fraction of ESE for potential antiviral properties. Among the examined compounds, quercetin and isoquercitrin displayed potent antiviral activities against both VZV and HCMV with no significant cytotoxic effects. Both compounds strongly suppressed the expression of VZV and HCMV immediate-early (IE) genes. Our collective results indicated that, in addition to PGG, quercetin and isoquercitrin are bioactive compounds in the EtOAc fraction of ESE that effectively inhibit human herpesvirus replication.

Citing Articles

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