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EANM Practice Guideline for Quantitative SPECT-CT

Abstract

Purpose: Quantitative SPECT-CT is a modality of growing importance with initial developments in post radionuclide therapy dosimetry, and more recent expansion into bone, cardiac and brain imaging together with the concept of theranostics more generally. The aim of this document is to provide guidelines for nuclear medicine departments setting up and developing their quantitative SPECT-CT service with guidance on protocols, harmonisation and clinical use cases.

Methods: These practice guidelines were written by members of the European Association of Nuclear Medicine Physics, Dosimetry, Oncology and Bone committees representing the current major stakeholders in Quantitative SPECT-CT. The guidelines have also been reviewed and approved by all EANM committees and have been endorsed by the European Association of Nuclear Medicine.

Conclusion: The present practice guidelines will help practitioners, scientists and researchers perform high-quality quantitative SPECT-CT and will provide a framework for the continuing development of quantitative SPECT-CT as an established modality.

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References
1.
Bailey D, Willowson K . An evidence-based review of quantitative SPECT imaging and potential clinical applications. J Nucl Med. 2013; 54(1):83-9. DOI: 10.2967/jnumed.112.111476. View

2.
Liu T, Karlsen M, Karlberg A, Redalen K . Hypoxia imaging and theranostic potential of [Cu][Cu(ATSM)] and ionic Cu(II) salts: a review of current evidence and discussion of the retention mechanisms. EJNMMI Res. 2020; 10(1):33. PMC: 7145880. DOI: 10.1186/s13550-020-00621-5. View

3.
Blaire T, Bailliez A, Ben Bouallegue F, Bellevre D, Agostini D, Manrique A . First assessment of simultaneous dual isotope (I/Tc) cardiac SPECT on two different CZT cameras: A phantom study. J Nucl Cardiol. 2017; 25(5):1692-1704. DOI: 10.1007/s12350-017-0841-z. View

4.
Dewaraja Y, Ljungberg M, Green A, Zanzonico P, Frey E, Bolch W . MIRD pamphlet No. 24: Guidelines for quantitative 131I SPECT in dosimetry applications. J Nucl Med. 2013; 54(12):2182-8. PMC: 3970715. DOI: 10.2967/jnumed.113.122390. View

5.
Ljungberg M, Celler A, Konijnenberg M, Eckerman K, Dewaraja Y, Sjogreen-Gleisner K . MIRD Pamphlet No. 26: Joint EANM/MIRD Guidelines for Quantitative 177Lu SPECT Applied for Dosimetry of Radiopharmaceutical Therapy. J Nucl Med. 2015; 57(1):151-62. DOI: 10.2967/jnumed.115.159012. View