First Assessment of Simultaneous Dual Isotope (I/Tc) Cardiac SPECT on Two Different CZT Cameras: A Phantom Study

Overview

Journal J Nucl Cardiol

Specialty Cardiology & Vascular Diseases

Date 2017 Mar 10

PMID 28275896

Citations 11

Authors

Tanguy Blaire

Alban Bailliez

Faycal Ben Bouallegue

Dimitri Bellevre

Denis Agostini

Alain Manrique

Affiliations

Soon will be listed here.

Abstract

Background: We studied the impact of simultaneous dual-isotope acquisition on I/Tc mismatch assessment using two CZT cameras (DNM 530c, GE Healthcare and DSPECT, Biosensors International).

Methods: We used an anthropomorphic torso phantom (respectively filled with a solution of I alone, Tc alone, and a mixture of I and Tc) and its cardiac insert with two defects mimicking two matched and mismatched defects. Mismatch extent and reconstructed image contrast were evaluated.

Results: The acquisition mode (single vs dual) significantly impacted (i) Tc (but not I) reconstructed segmental activities using both camera (P < .001), and (ii) image contrast (using I and DNM 530c, P < .0001; and using both I and Tc with DSPECT, P < .0001). However, the defect and mismatch size were not impacted by the type of acquisition. With both DNM 530c and DSPECT, Lin's concordance correlation coefficient and Bland-Altman analysis demonstrated an almost perfect concordance and agreement between single- and simultaneous dual-isotope segmental activity (I and Tc).

Conclusions: This study found no impact of the acquisition mode (single vs dual) or the type of camera (DSPECT vs DNM 530c) on I and Tc defect size and mismatch, providing a new step toward simultaneous dual-isotope acquisition for combined innervation and perfusion assessment.

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