Vitamin and Mineral Levels During Pregnancy

Overview

Journal Rev Assoc Med Bras (1992)

Specialty General Medicine

Date 2022 Nov 30

PMID 36449797

Authors

Kemal Hansu

Ismail Gurkan Cikim

Affiliations

Soon will be listed here.

Abstract

Objective: Numerous physiological changes occur during pregnancy, which affect both the mother and the fetus. The objective of this study was to evaluate the magnesium, calcium, phosphate, parathormone (PTH), and vitamin D levels in each trimester of pregnancy.

Methods: In this study, 30 pregnant women in the first trimester, 30 pregnant women in the second trimester, 30 pregnant women in the third trimester, and 30 healthy, non-pregnant women (control) in the same age group were included. The serum magnesium, calcium, phosphate, PTH, and vitamin D levels were measured in all the participants.

Results: No statistically significant difference was found in the PTH and phosphate levels within the groups. In contrast, a significant difference was found in the vitamin D, calcium, and magnesium levels (p<0.001 for all). By analyzing the differences between the groups, the vitamin D, calcium, and magnesium levels were found to decrease with increase in the gestational weeks.

Conclusion: For maintaining a healthy pregnancy and fetus, we recommend vitamin D, calcium, and magnesium levels to be included in routine follow-ups for each trimester and supplemented in case of deficiency.

Citing Articles

Minerals and Human Health: From Deficiency to Toxicity.

Razzaque M, Wimalawansa S Nutrients. 2025; 17(3).

PMID: 39940312 PMC: 11820417. DOI: 10.3390/nu17030454.

References

Takaya J . Small for Gestational Age and Magnesium: Intrauterine magnesium deficiency may induce metabolic syndrome in later life. AIMS Public Health. 2018; 2(4):793-803. PMC: 5690443. DOI: 10.3934/publichealth.2015.4.793. View

De-Regil L, Palacios C, Lombardo L, Pena-Rosas J . Vitamin D supplementation for women during pregnancy. Cochrane Database Syst Rev. 2016; (1):CD008873. DOI: 10.1002/14651858.CD008873.pub3. View

Perez-Lopez F, Pasupuleti V, Mezones-Holguin E, Benites-Zapata V, Thota P, Deshpande A . Effect of vitamin D supplementation during pregnancy on maternal and neonatal outcomes: a systematic review and meta-analysis of randomized controlled trials. Fertil Steril. 2015; 103(5):1278-88.e4. DOI: 10.1016/j.fertnstert.2015.02.019. View

Karras S, Wagner C, Castracane V . Understanding vitamin D metabolism in pregnancy: From physiology to pathophysiology and clinical outcomes. Metabolism. 2017; 86:112-123. DOI: 10.1016/j.metabol.2017.10.001. View

Meng D, Zhang Y, Ma S, Hu H, Li J, Yin W . The role of parathyroid hormone during pregnancy on the relationship between maternal vitamin D deficiency and fetal growth restriction: a prospective birth cohort study. Br J Nutr. 2020; 124(4):432-439. DOI: 10.1017/S0007114520001105. View

Hollis B, Wagner C . New insights into the vitamin D requirements during pregnancy. Bone Res. 2017; 5:17030. PMC: 5573964. DOI: 10.1038/boneres.2017.30. View

Zoroddu M, Aaseth J, Crisponi G, Medici S, Peana M, Nurchi V . The essential metals for humans: a brief overview. J Inorg Biochem. 2019; 195:120-129. DOI: 10.1016/j.jinorgbio.2019.03.013. View

Ganguly A, Tamblyn J, Finn-Sell S, Chan S, Westwood M, Gupta J . Vitamin D, the placenta and early pregnancy: effects on trophoblast function. J Endocrinol. 2017; 236(2):R93-R103. DOI: 10.1530/JOE-17-0491. View

Correia-Branco A, Rincon M, Pereira L, Wallingford M . Inorganic Phosphate in the Pathogenesis of Pregnancy-Related Complications. Int J Mol Sci. 2020; 21(15). PMC: 7432618. DOI: 10.3390/ijms21155283. View

10.

Chang S, Lee H . Vitamin D and health - The missing vitamin in humans. Pediatr Neonatol. 2019; 60(3):237-244. DOI: 10.1016/j.pedneo.2019.04.007. View

11.

Martineau A, Jolliffe D, Hooper R, Greenberg L, Aloia J, Bergman P . Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data. BMJ. 2017; 356:i6583. PMC: 5310969. DOI: 10.1136/bmj.i6583. View

12.

de Masi S, Bucagu M, Tuncalp O, Pena-Rosas J, Lawrie T, Oladapo O . Integrated Person-Centered Health Care for All Women During Pregnancy: Implementing World Health Organization Recommendations on Antenatal Care for a Positive Pregnancy Experience. Glob Health Sci Pract. 2017; 5(2):197-201. PMC: 5487083. DOI: 10.9745/GHSP-D-17-00141. View

13.

Uwitonze A, Razzaque M . Role of Magnesium in Vitamin D Activation and Function. J Am Osteopath Assoc. 2018; 118(3):181-189. DOI: 10.7556/jaoa.2018.037. View

14.

Pfotenhauer K, Shubrook J . Vitamin D Deficiency, Its Role in Health and Disease, and Current Supplementation Recommendations. J Am Osteopath Assoc. 2017; 117(5):301-305. DOI: 10.7556/jaoa.2017.055. View

15.

Bi W, Nuyt A, Weiler H, Leduc L, Santamaria C, Wei S . Association Between Vitamin D Supplementation During Pregnancy and Offspring Growth, Morbidity, and Mortality: A Systematic Review and Meta-analysis. JAMA Pediatr. 2018; 172(7):635-645. PMC: 6137512. DOI: 10.1001/jamapediatrics.2018.0302. View

16.

Hysaj O, Marques-Gallego P, Richard A, Elgizouli M, Nieters A, Quack Lotscher K . Parathyroid Hormone in Pregnancy: Vitamin D and Other Determinants. Nutrients. 2021; 13(2). PMC: 7911996. DOI: 10.3390/nu13020360. View

17.

Giammanco M, Di Majo D, La Guardia M, Aiello S, Crescimannno M, Flandina C . Vitamin D in cancer chemoprevention. Pharm Biol. 2015; 53(10):1399-434. DOI: 10.3109/13880209.2014.988274. View

18.

Urrutia-Pereira M, Sole D . [Vitamin D deficiency in pregnancy and its impact on the fetus, the newborn and in childhood]. Rev Paul Pediatr. 2015; 33(1):104-13. PMC: 4436962. DOI: 10.1016/j.rpped.2014.05.004. View

19.

Tamasauskiene L, Golubickaite I, Ugenskiene R, Sjakste N, Paramonova N, Wu L . Vitamin D receptor gene polymorphisms in atopy. Immun Inflamm Dis. 2021; 9(4):1153-1159. PMC: 8589349. DOI: 10.1002/iid3.487. View

20.

Yamanaka R, Tabata S, Shindo Y, Hotta K, Suzuki K, Soga T . Mitochondrial Mg(2+) homeostasis decides cellular energy metabolism and vulnerability to stress. Sci Rep. 2016; 6:30027. PMC: 4960558. DOI: 10.1038/srep30027. View