Parathyroid Hormone in Pregnancy: Vitamin D and Other Determinants

Overview

Journal Nutrients

Date 2021 Jan 28

PMID 33504033

Citations 6

Authors

Ola Hysaj

Patricia Marques-Gallego

Aline Richard

Magdeldin Elgizouli

Alexandra Nieters

Katharina C Quack Lotscher

Sabine Rohrmann

Affiliations

Soon will be listed here.

Abstract

We aimed to assess the parathyroid hormone (PTH) concentration in pregnant women at the beginning of pregnancy (1st trimester) and within days before delivery (3rd trimester) and evaluate its determinants. From September 2014 through December 2015 in a cross-sectional study, 204 women in the 1st trimester of pregnancy and 203 women in the 3rd trimester of pregnancy were recruited. Blood samples were collected to measure PTH and circulating 25-hydroxy-vitamin D (25(OH)D) concentrations. Lifestyle and demographic data were collected using a questionnaire. Serum 25(OH)D and PTH were inversely correlated in both early and late pregnancy. Our analyses suggest that in the 3rd trimester of pregnancy, a 25(OH)D level of 18.9 ng/mL (47.3 nmol/L) could serve as an inflection point for the maximal suppression of PTH. Statistically significant determinants of PTH concentrations in multiple regression were 25(OH)D concentrations, season, multiparity and education of the partner (all < 0.05) in early pregnancy. In late pregnancy, 25(OH)D concentrations and country of origin were statistically significant determinants of PTH concentrations (all < 0.05). These factors and their effect on PTH appear to be vastly determined by 25(OH)D; however, they might also affect PTH through other mechanisms besides 25(OH)D.

Citing Articles

Vitamin D Intake and Serum Levels in Pregnant and Postpartum Women.

Meija L, Piskurjova A, Nikolajeva K, Aizbalte O, Rezgale R, Lejnieks A Nutrients. 2023; 15(15).

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The association of parathyroid hormone with serum 25-hydroxyvitamin during pregnancy.

Kazemian E, Madreseh E, Azizi F, Ashrafivand S, Saleh Gargari S, Mansournia M J Nutr Sci. 2023; 12:e1.

PMID: 36721726 PMC: 9869095. DOI: 10.1017/jns.2022.110.

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The Parathyroid Hormone-Related Protein/Parathyroid Hormone 1 Receptor Axis in Adipose Tissue.

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Parathyroid hormone in Sri Lankan pregnant women: Vitamin D and other determinants.

Kaneshapillai A, Hettiaratchi U, Prathapan S, Liyanage G PLoS One. 2021; 16(10):e0258381.

PMID: 34624060 PMC: 8500411. DOI: 10.1371/journal.pone.0258381.

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