Fast Quinazolinone Synthesis by Combining Enzymatic Catalysis and Photocatalysis

Overview

Journal Photochem Photobiol Sci

Publisher Springer

Specialties Biology
Chemistry

Date 2022 Nov 29

PMID 36445645

Authors

Liang Jin

Zhanggao Le

Qiangwen Fan

Jiangnan Yang

Can Zhang

Qian Li

Zongbo Xie

Affiliations

Soon will be listed here.

Abstract

A fast and highly efficient method for the synthesis of functionalized quinazolinones by combining enzymatic catalysis and photocatalysis is reported. The α-Chymotrypsin catalyzed the cyclization of aldehyde and 2-aminobenzamide, which was subsequently followed by White LED-induced oxidation of 2-phenyl-2, 3-dihydroquinazolin-4(1H)-one to obtain quinazolinone. The reaction process was highly efficient with a reaction yield of 99% in just 2 h, and a wide range of quinazolinones could be synthesized. Furthermore, the plausible mechanism was investigated by control experiments and DFT calculations. This protocol provides an alternative synthetic route for the preparation of quinazolinone derivatives.

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