Aerobic Oxidative Synthesis of Quinazolinones and Benzothiazoles in the Presence of Laccase/DDQ As a Bioinspired Cooperative Catalytic System Under Mild Conditions

Overview

Journal RSC Adv

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2022 May 2

PMID 35498453

Authors

Nadia Ghorashi

Zahra Shokri

Reza Moradi

Amira Abdelrasoul

Amin Rostami

Affiliations

Soon will be listed here.

Abstract

The current study applied laccase/DDQ as a bioinspired cooperative catalytic system for the synthesis of quinazolinones (80-95% yield) and benzothiazoles (65-98% yield) using air or O as ideal oxidants in aqueous media at ambient temperature. The aerobic oxidative cyclization reactions occur in two steps: (i) chemical cyclization; (ii) chemoenzymatic oxidation. These methods are more environment-friendly, efficient, simple and practical than other reported methods due to the use of O as an oxidant, laccase as an eco-friendly biocatalyst, aqueous media as the solvent and free from any toxic transition metal and halide catalysts. Therefore, these methods can be applied in pharmaceutical and other sensitive synthetic procedures.

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