Investigating the Eukaryotic Host-like SLiMs in Microbial Mimitopes and Their Potential As Novel Drug Targets for Treating Autoimmune Diseases

Overview

Journal Front Microbiol

Specialty Microbiology

Date 2022 Nov 21

PMID 36406429

Authors

Anjali Garg

Neelja Singhal

Manish Kumar

Affiliations

Soon will be listed here.

References

Yan J, Dunker A, Uversky V, Kurgan L . Molecular recognition features (MoRFs) in three domains of life. Mol Biosyst. 2015; 12(3):697-710. DOI: 10.1039/c5mb00640f. View

Li H, Xu H, Zhou Y, Zhang J, Long C, Li S . The phosphothreonine lyase activity of a bacterial type III effector family. Science. 2007; 315(5814):1000-3. DOI: 10.1126/science.1138960. View

Dolan P, Roth A, Xue B, Sun R, Dunker A, Uversky V . Intrinsic disorder mediates hepatitis C virus core-host cell protein interactions. Protein Sci. 2014; 24(2):221-35. PMC: 4315660. DOI: 10.1002/pro.2608. View

Yang Z . PAML 4: phylogenetic analysis by maximum likelihood. Mol Biol Evol. 2007; 24(8):1586-91. DOI: 10.1093/molbev/msm088. View

Coppieters K, Wiberg A, von Herrath M . Viral infections and molecular mimicry in type 1 diabetes. APMIS. 2012; 120(12):941-9. PMC: 5774991. DOI: 10.1111/apm.12011. View

Dinkel H, Van Roey K, Michael S, Davey N, Weatheritt R, Born D . The eukaryotic linear motif resource ELM: 10 years and counting. Nucleic Acids Res. 2013; 42(Database issue):D259-66. PMC: 3964949. DOI: 10.1093/nar/gkt1047. View

Xue B, Blocquel D, Habchi J, Uversky A, Kurgan L, Uversky V . Structural disorder in viral proteins. Chem Rev. 2014; 114(13):6880-911. DOI: 10.1021/cr4005692. View

Comas I, Chakravartti J, Small P, Galagan J, Niemann S, Kremer K . Human T cell epitopes of Mycobacterium tuberculosis are evolutionarily hyperconserved. Nat Genet. 2010; 42(6):498-503. PMC: 2883744. DOI: 10.1038/ng.590. View

Phelan J, Grabowska A, Sepulveda N . A potential antigenic mimicry between viral and human proteins linking Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) with autoimmunity: The case of HPV immunization. Autoimmun Rev. 2020; 19(4):102487. DOI: 10.1016/j.autrev.2020.102487. View

10.

Frese S, Schubert W, Findeis A, Marquardt T, Roske Y, Stradal T . The phosphotyrosine peptide binding specificity of Nck1 and Nck2 Src homology 2 domains. J Biol Chem. 2006; 281(26):18236-45. DOI: 10.1074/jbc.M512917200. View

11.

Higashi H, Tsutsumi R, Fujita A, Yamazaki S, Asaka M, Azuma T . Biological activity of the Helicobacter pylori virulence factor CagA is determined by variation in the tyrosine phosphorylation sites. Proc Natl Acad Sci U S A. 2002; 99(22):14428-33. PMC: 137900. DOI: 10.1073/pnas.222375399. View

12.

Hagai T, Azia A, Babu M, Andino R . Use of host-like peptide motifs in viral proteins is a prevalent strategy in host-virus interactions. Cell Rep. 2014; 7(5):1729-1739. PMC: 4089993. DOI: 10.1016/j.celrep.2014.04.052. View

13.

Dosztanyi Z, Meszaros B, Simon I . ANCHOR: web server for predicting protein binding regions in disordered proteins. Bioinformatics. 2009; 25(20):2745-6. PMC: 2759549. DOI: 10.1093/bioinformatics/btp518. View

14.

Samano-Sanchez H, Gibson T . Mimicry of Short Linear Motifs by Bacterial Pathogens: A Drugging Opportunity. Trends Biochem Sci. 2020; 45(6):526-544. DOI: 10.1016/j.tibs.2020.03.003. View

15.

LARKIN M, Blackshields G, Brown N, Chenna R, McGettigan P, McWilliam H . Clustal W and Clustal X version 2.0. Bioinformatics. 2007; 23(21):2947-8. DOI: 10.1093/bioinformatics/btm404. View

16.

Schwegmann A, Brombacher F . Host-directed drug targeting of factors hijacked by pathogens. Sci Signal. 2008; 1(29):re8. DOI: 10.1126/scisignal.129re8. View

17.

Polymeros D, Tsiamoulos Z, Koutsoumpas A, Smyk D, Mytilinaiou M, Triantafyllou K . Bioinformatic and immunological analysis reveals lack of support for measles virus related mimicry in Crohn's disease. BMC Med. 2014; 12:139. PMC: 4171545. DOI: 10.1186/s12916-014-0139-9. View

18.

Ascherio A, Munger K . Environmental risk factors for multiple sclerosis. Part II: Noninfectious factors. Ann Neurol. 2007; 61(6):504-13. DOI: 10.1002/ana.21141. View

19.

Yang Z . Inference of selection from multiple species alignments. Curr Opin Genet Dev. 2002; 12(6):688-94. DOI: 10.1016/s0959-437x(02)00348-9. View

20.

Davey N, Van Roey K, Weatheritt R, Toedt G, Uyar B, Altenberg B . Attributes of short linear motifs. Mol Biosyst. 2011; 8(1):268-81. DOI: 10.1039/c1mb05231d. View