Viral Infections and Molecular Mimicry in Type 1 Diabetes

Overview

Journal APMIS

Specialties Allergy & Immunology
Microbiology
Pathology

Date 2012 Oct 12

PMID 23051179

Citations 43

Authors

Ken T Coppieters

Anna Wiberg

Matthias G von Herrath

Affiliations

Soon will be listed here.

Abstract

Type 1 diabetes (T1D) is a disease characterized by inflammation of pancreatic islets associated with autoimmunity against insulin-producing beta cells, leading to their progressive destruction. The condition constitutes a significant and worldwide problem to human health, particularly because of its rapid, but thus far unexplained, increase in incidence. Environmental factors such as viral infections are thought to account for this trend. While there is no lack of reports associating viral infections toT1D, it has proven difficult to establish which immunological processes link viral infections to disease onset or progression. One of the commonly discussed pathways is molecular mimicry, a mechanism that encompasses cross-reactive immunity against epitopes shared between viruses and beta cells. In this review, we will take a closer look at mechanistic evidence for a potential role of viruses in T1D, with a special focus on molecular mimicry.

Citing Articles

Type 1 diabetes: immune pathology and novel therapeutic approaches.

Ling E, Lemos J, Hirani K, von Herrath M Diabetol Int. 2024; 15(4):761-776.

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Decoding the relationship between cow's milk proteins and development of type 1 diabetes mellitus.

Andrade L, Oliveira G, de Oliveira L, Bittencourt A, Baumgarth Y, Oliveira L Arch Endocrinol Metab. 2024; 68:e230248.

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The Role of the Nrf2 Pathway in Airway Tissue Damage Due to Viral Respiratory Infections.

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The relationship between SARS-CoV-2 infection and type 1 diabetes mellitus.

Debuysschere C, Nekoua M, Alidjinou E, Hober D Nat Rev Endocrinol. 2024; 20(10):588-599.

PMID: 38890459 DOI: 10.1038/s41574-024-01004-9.

The Impact of Microbiota-Immunity-Hormone Interactions on Autoimmune Diseases and Infection.

Martinelli S, Nannini G, Cianchi F, Coratti F, Amedei A Biomedicines. 2024; 12(3).

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