Bioprinting and Its Use in Tumor-On-A-Chip Technology for Cancer Drug Screening: A Review

Overview

Journal Int J Bioprint

Specialty Biomedical Engineering

Date 2022 Nov 21

PMID 36404793

Authors

Lingling Fang

Yu Liu

Junfeng Qiu

Weiqing Wan

Affiliations

Soon will be listed here.

Abstract

The rising global incidence of cancer and high attrition rates of anticancer drugs make it imperative to design novel screening platforms to increase the success rate of chemotherapeutic agents. Advances in cell culture models from two-dimensional to three-dimensional platforms, along with microfluidics, have resulted in the creation of tumor-on-a-chip technology, which enables high-throughput molecular screening and helps to simulate the dynamic tumor microenvironment. Furthermore, advancements in bioprinting have allowed the structural and physiological aspects of the tumor to be recreated accurately and help to mimic cell-cell interactions and cell-extracellular matrix. This paper provides a comprehensive review of three-dimensional bioprinting to fabricate a tumor-on-a-chip platform to advance the discovery and screening of anticancer agents and provides a perspective on the challenges and future directions associated with the adoption of this technology to advance cancer research.

Citing Articles

Improving tumor microenvironment assessment in chip systems through next-generation technology integration.

Gaebler D, Hachey S, Hughes C Front Bioeng Biotechnol. 2024; 12:1462293.

PMID: 39386043 PMC: 11461320. DOI: 10.3389/fbioe.2024.1462293.

A 3D Bio-Printed-Based Model for Pancreatic Ductal Adenocarcinoma.

Godier C, Baka Z, Lamy L, Gribova V, Marchal P, Lavalle P Diseases. 2024; 12(9).

PMID: 39329875 PMC: 11431387. DOI: 10.3390/diseases12090206.

Targeted Cancer Therapy-on-A-Chip.

Abed H, Radha R, Anjum S, Paul V, AlSawaftah N, Pitt W Adv Healthc Mater. 2024; 13(29):e2400833.

PMID: 39101627 PMC: 11582519. DOI: 10.1002/adhm.202400833.

Biosensor-Enhanced Organ-on-a-Chip Models for Investigating Glioblastoma Tumor Microenvironment Dynamics.

Thenuwara G, Javed B, Singh B, Tian F Sensors (Basel). 2024; 24(9).

PMID: 38732975 PMC: 11086276. DOI: 10.3390/s24092865.

Applications of 3D Bioprinting Technology to Brain Cells and Brain Tumor Models: Special Emphasis to Glioblastoma.

Ozbek I, Saybasili H, Ulgen K ACS Biomater Sci Eng. 2024; 10(5):2616-2635.

PMID: 38664996 PMC: 11094688. DOI: 10.1021/acsbiomaterials.3c01569.

References

Levental K, Yu H, Kass L, Lakins J, Egeblad M, Erler J . Matrix crosslinking forces tumor progression by enhancing integrin signaling. Cell. 2009; 139(5):891-906. PMC: 2788004. DOI: 10.1016/j.cell.2009.10.027. View

Hoffmann O, Ilmberger C, Magosch S, Joka M, Jauch K, Mayer B . Impact of the spheroid model complexity on drug response. J Biotechnol. 2015; 205:14-23. DOI: 10.1016/j.jbiotec.2015.02.029. View

Peppicelli S, Andreucci E, Ruzzolini J, Laurenzana A, Margheri F, Fibbi G . The acidic microenvironment as a possible niche of dormant tumor cells. Cell Mol Life Sci. 2017; 74(15):2761-2771. PMC: 11107711. DOI: 10.1007/s00018-017-2496-y. View

Velasco V, Shariati S, Esfandyarpour R . Microtechnology-based methods for organoid models. Microsyst Nanoeng. 2021; 6:76. PMC: 8433138. DOI: 10.1038/s41378-020-00185-3. View

Rhee S, Puetzer J, Mason B, Reinhart-King C, Bonassar L . 3D Bioprinting of Spatially Heterogeneous Collagen Constructs for Cartilage Tissue Engineering. ACS Biomater Sci Eng. 2021; 2(10):1800-1805. DOI: 10.1021/acsbiomaterials.6b00288. View

Kapalczynska M, Kolenda T, Przybyla W, Zajaczkowska M, Teresiak A, Filas V . 2D and 3D cell cultures - a comparison of different types of cancer cell cultures. Arch Med Sci. 2018; 14(4):910-919. PMC: 6040128. DOI: 10.5114/aoms.2016.63743. View

McMaster R, Hoefner C, Hrynevich A, Blum C, Wiesner M, Wittmann K . Tailored Melt Electrowritten Scaffolds for the Generation of Sheet-Like Tissue Constructs from Multicellular Spheroids. Adv Healthc Mater. 2019; 8(7):e1801326. DOI: 10.1002/adhm.201801326. View

Chiantore M, Mangino G, Zangrillo M, Iuliano M, Affabris E, Fiorucci G . Role of the microenvironment in tumourigenesis: focus on virus-induced tumors. Curr Med Chem. 2014; 22(8):958-74. DOI: 10.2174/0929867322666141212121751. View

Auner A, Tasneem K, Markov D, McCawley L, Hutson M . Chemical-PDMS binding kinetics and implications for bioavailability in microfluidic devices. Lab Chip. 2019; 19(5):864-874. PMC: 6512955. DOI: 10.1039/c8lc00796a. View

10.

Albini A, Bruno A, Gallo C, Pajardi G, Noonan D, Dallaglio K . Cancer stem cells and the tumor microenvironment: interplay in tumor heterogeneity. Connect Tissue Res. 2015; 56(5):414-25. PMC: 4673538. DOI: 10.3109/03008207.2015.1066780. View

11.

Izumchenko E, Paz K, Ciznadija D, Sloma I, Katz A, Vasquez-Dunddel D . Patient-derived xenografts effectively capture responses to oncology therapy in a heterogeneous cohort of patients with solid tumors. Ann Oncol. 2017; 28(10):2595-2605. PMC: 5834154. DOI: 10.1093/annonc/mdx416. View

12.

Hamid Q, Wang C, Zhao Y, Snyder J, Sun W . A three-dimensional cell-laden microfluidic chip for in vitro drug metabolism detection. Biofabrication. 2014; 6(2):025008. DOI: 10.1088/1758-5082/6/2/025008. View

13.

Monteiro M, Zhang Y, Gaspar V, Mano J . 3D-bioprinted cancer-on-a-chip: level-up organotypic in vitro models. Trends Biotechnol. 2021; 40(4):432-447. PMC: 8916962. DOI: 10.1016/j.tibtech.2021.08.007. View

14.

Zhang N, Yin Y, Xu S, Chen W . 5-Fluorouracil: mechanisms of resistance and reversal strategies. Molecules. 2008; 13(8):1551-69. PMC: 6244944. DOI: 10.3390/molecules13081551. View

15.

Fang Y, Eglen R . Three-Dimensional Cell Cultures in Drug Discovery and Development. SLAS Discov. 2017; 22(5):456-472. PMC: 5448717. DOI: 10.1177/1087057117696795. View

16.

Robado de Lope L, Alcibar O, Lopez A, Hergueta-Redondo M, Peinado H . Tumour-adipose tissue crosstalk: fuelling tumour metastasis by extracellular vesicles. Philos Trans R Soc Lond B Biol Sci. 2017; 373(1737). PMC: 5717439. DOI: 10.1098/rstb.2016.0485. View

17.

Yi H, Jeong Y, Kim Y, Choi Y, Moon H, Park S . A bioprinted human-glioblastoma-on-a-chip for the identification of patient-specific responses to chemoradiotherapy. Nat Biomed Eng. 2019; 3(7):509-519. DOI: 10.1038/s41551-019-0363-x. View

18.

Imamura Y, Mukohara T, Shimono Y, Funakoshi Y, Chayahara N, Toyoda M . Comparison of 2D- and 3D-culture models as drug-testing platforms in breast cancer. Oncol Rep. 2015; 33(4):1837-43. DOI: 10.3892/or.2015.3767. View

19.

Bi J, Tian Z . NK Cell Exhaustion. Front Immunol. 2017; 8:760. PMC: 5487399. DOI: 10.3389/fimmu.2017.00760. View

20.

Erdogan B, Ao M, White L, Means A, Brewer B, Yang L . Cancer-associated fibroblasts promote directional cancer cell migration by aligning fibronectin. J Cell Biol. 2017; 216(11):3799-3816. PMC: 5674895. DOI: 10.1083/jcb.201704053. View