5-Fluorouracil: Mechanisms of Resistance and Reversal Strategies

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2008 Sep 17

PMID 18794772

Citations 280

Authors

Ning Zhang

Ying Yin

Sheng-Jie Xu

Wei-Shan Chen

Affiliations

Soon will be listed here.

Abstract

The purpose of this work is to review the published studies on the mechanisms of action and resistance of 5-fluorouracil. The review is divided into three main sections: mechanisms of anti-tumor action, studies of the resistance to the drug, and procedures for the identification of new genes involved in resistance with microarray techniques. The details of the induction and reversal of the drug resistance are also described.

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