Notch Signaling is Necessary for Adult, but Not Fetal, Development of RORγt(+) Innate Lymphoid Cells

Overview

Journal Nat Immunol

Date 2011 Sep 13

PMID 21909092

Citations 133

Authors

Cecilie Possot

Sandrine Schmutz

Sylvestre Chea

Laurent Boucontet

Anne Louise

Ana Cumano

Rachel Golub

Affiliations

Soon will be listed here.

Abstract

The transcription factor RORγt is required for the development of several innate lymphoid populations, such as lymphoid tissue-inducer cells (LTi cells) and cells that secrete interleukin 17 (IL-17) or IL-22. The progenitor cells as well as the developmental stages that lead to the emergence of RORγt(+) innate lymphoid cells (ILCs) remain undefined. Here we identify the chemokine receptor CXCR6 as an additional marker of the development of ILCs and show that common lymphoid progenitors lost B cell and T cell potential as they successively acquired expression of the integrin α(4)β(7) and CXCR6. Whereas fetal RORγt(+) cells matured in the fetal liver environment, adult bone marrow-derived RORγt(+) ILCs matured outside the bone marrow, in a Notch2-dependent manner. Therefore, fetal and adult environments influence the differentiation of RORγt(+) cells differently.

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