Dysregulated Lipid Synthesis by Oncogenic IDH1 Mutation Is a Targetable Synthetic Lethal Vulnerability

Overview

Journal Cancer Discov

Specialty Oncology

Date 2022 Nov 10

PMID 36355448

Authors

Daniel Thomas

Manhong Wu

Yusuke Nakauchi

Ming Zheng

Chloe A L Thompson-Peach

Kelly Lim

Niklas Landberg

Thomas Kohnke

Nirmal Robinson

Satinder Kaur

Monika Kutyna

Melissa Stafford

Devendra Hiwase

Andreas Reinisch

Gary Peltz

Ravindra Majeti

Affiliations

Soon will be listed here.

Abstract

Significance: Oncogenic mutations in both IDH1 and IDH2 produce 2-hydroxyglutarate and are generally considered equivalent in terms of pathogenesis and targeting. Using comprehensive metabolomic analysis, we demonstrate unexpected metabolic differences in fatty acid metabolism between mutant IDH1 and IDH2 in patient samples with targetable metabolic interventions. See related commentary by Robinson and Levine, p. 266. This article is highlighted in the In This Issue feature, p. 247.

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