Cumulative Live Birth Rate Per Oocyte Aspiration in Artificial Reproduction Technology: A Retrospective Observational Study of the Association Between Maternal Age and the Number of Oocytes Retrieved in an Indian Population

Overview

Journal J Hum Reprod Sci

Date 2022 Nov 7

PMID 36341006

Authors

Devika Gunasheela

Mahesh Ashwini

Lohith Chengappa Appaneravanda

Hita Nayak

Affiliations

Soon will be listed here.

Abstract

Background: The association between cumulative live birth rate (CLBR) and oocyte aspiration in the context of maternal age is not well understood in the Indian population.

Aims: To find the relationship between CLBR and a single oocyte aspiration.

Settings And Design: This is a retrospective study analysing the data of 1989 women who underwent fertilisation (IVF) between January 2015 and December 2019, at Gunasheela Surgical and Maternity Hospital, India.

Materials And Methods: Participants were divided into two groups based on age: ≤35 (group I, = 1665) and >35 (Group II, = 324). CLBR per single oocyte aspiration in fresh and subsequent three frozen embryo transfer cycles was estimated.

Statistical Analysis Used: Logistic regression analysis was used to show the likelihood of pregnancy rate, and CLBR per aspiration after treatment was represented as odd's ratios (OR) with 95% confidence intervals.

Results: Maximal CLBR for Groups I and II was 81.25% with >25 oocytes and 75% with 16-20 oocytes, respectively. In the fresh ET cycle, maximal pregnancy and live birth rates were observed in 6-10 oocytes for Group I (54% and 41%) and in 16-20 oocytes for Group II (75% and 75%). The ORs for pregnancy rate ( = 0.01) and CLBR ( = 0.007) increased with an increase in the number of oocytes retrieved. The ORs for pregnancy rate and CLBR for Group II were 0.68 ( = 0.002) and 0.58 ( = 0.00002), respectively as compared to Group I. Optimal oocytes required to achieve positive IVF outcomes in fresh/frozen ET cycles were low in Group I (6-10 oocytes), but higher in Group II (16-20 oocytes).

Conclusion: Robust positive relationship was observed between the number of oocytes retrieved and CLBR in women of both age groups.

Citing Articles

Regulation of ovarian function by growth hormone: Potential intervention of ovarian aging.

Han L, Tian H, Guo X, Zhang L Front Endocrinol (Lausanne). 2023; 13:1072313.

PMID: 36699044 PMC: 9868403. DOI: 10.3389/fendo.2022.1072313.

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