The Roles of MMP8/MMP10 Polymorphisms in Ischemic Stroke Susceptibility

Overview

Journal Brain Behav

Specialty Psychology

Date 2022 Oct 25

PMID 36282475

Authors

Yong Zhao

Qi Zhang

Xiaobo Zhang

Yu Zhang

Ying Lu

Xiaojuan Ma

Weiping Li

Xiaochen Niu

Gejuan Zhang

Mingze Chang

Wenzhen Shi

Ye Tian

Affiliations

Soon will be listed here.

Abstract

Background: Ischemic stroke (IS), a multifactorial and polygenic disease, is the most common cause of death. This study aimed to determine the roles of MMP8/MMP10 polymorphisms in IS susceptibility in the Chinese Han population.

Methods: MMP8 rs1940475 and rs3765620, and MMP10 rs17860949 from 700 IS patients and 700 controls were genotyped by the MassARRAY iPLEX platform. The impact of polymorphisms on IS risk was evaluated by logistic regression analysis.

Results: Our study indicated that rs17860949 in MMP10 was significantly associated with a reduced risk of IS (OR = 0.632, p = .002). Precisely, stratification analysis showed that rs17860949 was relate to a decreased susceptibility to IS in patients aged > 55 years (OR = 0.472, p < .001), males (OR = 0.632, p = .012), nonsmokers (OR = 0.610, p = .017), and nondrinkers (OR = 0.559, p = .006). All these significant findings were verified by false-positive report probability test. Furthermore, GG genotype and AG genotype in MMP8 rs3765620 polymorphism were related to a reduced triglycerides concentration (p = .018).

Conclusion: Our study suggests that rs17860949 in MMP10 may play a protective role in IS in the Chinese Han population.

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