Association Study for the Role of MMP8 Gene Polymorphisms in Colorectal Cancer Susceptibility

Overview

Journal BMC Cancer

Publisher Biomed Central

Specialty Oncology

Date 2023 Nov 29

PMID 38031100

Authors

Shuyong Yu

Jiajia Cheng

Ping Li

Le Tian

Zhuang Chen

Zhaowei Chen

Yongyu Li

Jian Song

Affiliations

Soon will be listed here.

Abstract

Background: Colorectal cancer (CRC) is one of the most common malignant tumors, influenced by several genetic loci in its clinical phenotypes. The aim of this study was to determine the relationship between the MMP8 gene polymorphism and CRC risk in the Chinese Han population.

Method: This study recruited 688 CRC patients and 690 healthy controls. The relationship between MMP8 polymorphism and CRC susceptibility was assessed by calculating the odds ratio (OR) and 95% confidence interval (CI) after stratifying by age, gender, body mass index (BMI), smoking, and alcohol consumption under a multi-genetic model.

Results: MMP8 rs3740938 was associated with increased CRC predisposition (p = 0.016, OR = 1.24, 95% CI: 1.04-1.48), and this association was detected particularly in subjects aged > 60 years, females, people with BMI > 24 kg/m, smokers, and drinkers. Moreover, rs3740938 was found to be associated with the pathological type of rectal cancer.

Conclusions: Our results first displayed that rs3740938 in MMP8 was a risk factor for CRC predisposition. This finding may provide a new biological perspective for understanding the role of the MMP8 gene in CRC pathogenesis.

Citing Articles

Association of Methylenetetrahydrofolate Reductase rs1801133 Gene Polymorphism with Cancer Risk and Septin 9 Methylation in Patients with Colorectal Cancer.

Huang Y, Su T, Duan Q, Wei X, Fan X, Wan J J Gastrointest Cancer. 2024; 55(2):778-786.

PMID: 38252186 PMC: 11186932. DOI: 10.1007/s12029-024-01020-y.

References

Oeth P, del Mistro G, Marnellos G, Shi T, Van Den Boom D . Qualitative and quantitative genotyping using single base primer extension coupled with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MassARRAY). Methods Mol Biol. 2009; 578:307-43. DOI: 10.1007/978-1-60327-411-1_20. View

Insodaite R, Liutkevicius V, Uloza V, Solovejute R, Smalinskiene A . Association Between Gene Polymorphisms and Laryngeal Squamous Cell Carcinoma. Anticancer Res. 2020; 40(4):2003-2009. DOI: 10.21873/anticanres.14156. View

Wacholder S, Chanock S, Garcia-Closas M, El Ghormli L, Rothman N . Assessing the probability that a positive report is false: an approach for molecular epidemiology studies. J Natl Cancer Inst. 2004; 96(6):434-42. PMC: 7713993. DOI: 10.1093/jnci/djh075. View

Reijonen P, Peltonen R, Tervahartiala T, Sorsa T, Isoniemi H . Serum Matrix Metalloproteinase-8 and Myeloperoxidase Predict Survival after Resection of Colorectal Liver Metastases. Oncology. 2021; 99(12):766-779. DOI: 10.1159/000518955. View

Wang K, Zhou Y, Li G, Wen X, Kou Y, Yu J . MMP8 and MMP9 gene polymorphisms were associated with breast cancer risk in a Chinese Han population. Sci Rep. 2018; 8(1):13422. PMC: 6128940. DOI: 10.1038/s41598-018-31664-3. View

Murugan A, Qasem E, Al-Hindi H, Alzahrani A . Analysis of and somatic mutations in differentiated thyroid cancers. Mol Clin Oncol. 2021; 15(4):210. PMC: 8375036. DOI: 10.3892/mco.2021.2373. View

. Global, regional, and national burden of colorectal cancer and its risk factors, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet Gastroenterol Hepatol. 2022; 7(7):627-647. PMC: 9192760. DOI: 10.1016/S2468-1253(22)00044-9. View

Larsson S, Carter P, Kar S, Vithayathil M, Mason A, Michaelsson K . Smoking, alcohol consumption, and cancer: A mendelian randomisation study in UK Biobank and international genetic consortia participants. PLoS Med. 2020; 17(7):e1003178. PMC: 7377370. DOI: 10.1371/journal.pmed.1003178. View

Qu R, Ma Y, Zhang Z, Fu W . Increasing burden of colorectal cancer in China. Lancet Gastroenterol Hepatol. 2022; 7(8):700. DOI: 10.1016/S2468-1253(22)00156-X. View

10.

Bull C, Bell J, Murphy N, Sanderson E, Davey Smith G, Timpson N . Adiposity, metabolites, and colorectal cancer risk: Mendelian randomization study. BMC Med. 2020; 18(1):396. PMC: 7745469. DOI: 10.1186/s12916-020-01855-9. View

11.

Tai J, Sun D, Wang X, Kang Z . Matrix metalloproteinase-8 rs11225395 polymorphism correlates with colorectal cancer risk and survival in a Chinese Han population: a case-control study. Aging (Albany NY). 2020; 12(19):19618-19627. PMC: 7732324. DOI: 10.18632/aging.103930. View

12.

Pezeshkian Z, Nobili S, Peyravian N, Shojaee B, Nazari H, Soleimani H . Insights into the Role of Matrix Metalloproteinases in Precancerous Conditions and in Colorectal Cancer. Cancers (Basel). 2021; 13(24). PMC: 8699154. DOI: 10.3390/cancers13246226. View

13.

Biller L, Schrag D . Diagnosis and Treatment of Metastatic Colorectal Cancer: A Review. JAMA. 2021; 325(7):669-685. DOI: 10.1001/jama.2021.0106. View

14.

Zhao Y, Zhang Q, Zhang X, Zhang Y, Lu Y, Ma X . The roles of MMP8/MMP10 polymorphisms in ischemic stroke susceptibility. Brain Behav. 2022; 12(12):e2797. PMC: 9759140. DOI: 10.1002/brb3.2797. View

15.

Bartnykaite A, Savukaityte A, Bekampyte J, Ugenskiene R, Laukaitiene D, Korobeinikova E . The Role of Matrix Metalloproteinase Single-Nucleotide Polymorphisms in the Clinicopathological Properties of Breast Cancer. Biomedicines. 2022; 10(8). PMC: 9405670. DOI: 10.3390/biomedicines10081891. View

16.

Sung H, Ferlay J, Siegel R, Laversanne M, Soerjomataram I, Jemal A . Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021; 71(3):209-249. DOI: 10.3322/caac.21660. View

17.

Ellis J, Ong B . The MassARRAY System for Targeted SNP Genotyping. Methods Mol Biol. 2016; 1492:77-94. DOI: 10.1007/978-1-4939-6442-0_5. View

18.

Juurikka K, Butler G, Salo T, Nyberg P, Astrom P . The Role of MMP8 in Cancer: A Systematic Review. Int J Mol Sci. 2019; 20(18). PMC: 6770849. DOI: 10.3390/ijms20184506. View

19.

Hagman H, Bendahl P, Lidfeldt J, Belting M, Johnsson A . Protein array profiling of circulating angiogenesis-related factors during bevacizumab containing treatment in metastatic colorectal cancer. PLoS One. 2018; 13(12):e0209838. PMC: 6310295. DOI: 10.1371/journal.pone.0209838. View

20.

Dvornyk V, Ponomarenko I, Minyaylo O, Reshetnikov E, Churnosov M . Association of the functionally significant polymorphisms of the MMP9 gene with H. pylori-positive gastric ulcer in the Caucasian population of Central Russia. PLoS One. 2021; 16(9):e0257060. PMC: 8423286. DOI: 10.1371/journal.pone.0257060. View