The Regulatory Role of PDE4B in the Progression of Inflammatory Function Study

Overview

Journal Front Pharmacol

Date 2022 Oct 24

PMID 36278172

Authors

Yue Su

Jiaxiang Ding

Fan Yang

Cuixia He

Yuanyuan Xu

Xingyu Zhu

Huan Zhou

Hongtao Li

Affiliations

Soon will be listed here.

Abstract

Inflammation is a response of the body to external stimuli (eg. chemical irritants, bacteria, viruses, etc.), and when the stimuli are persistent, they tend to trigger chronic inflammation. The presence of chronic inflammation is an important component of the tumor microenvironment produced by a variety of inflammatory cells (eg. macrophages, neutrophils, leukocytes, etc.). The relationship between chronic inflammation and cancer development has been widely accepted, and chronic inflammation has been associated with the development of many cancers, including chronic bronchitis and lung cancer, cystitis inducing bladder cancer. Moreover, chronic colorectitis is more likely to develop into colorectal cancer. Therefore, the specific relationship and cellular mechanisms between inflammation and cancer are a hot topic of research. Recent studies have identified phosphodiesterase 4B (PDE4B), a member of the phosphodiesterase (PDEs) protein family, as a major cyclic AMP (cAMP) metabolizing enzyme in inflammatory cells, and the therapeutic role of PDE4B as chronic inflammation, cancer. In this review, we will present the tumors associated with chronic inflammation, and PDE4B potential clinical application.

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References

Guo B, Lager K, Henningson J, Miller L, Schlink S, Kappes M . Experimental infection of United States swine with a Chinese highly pathogenic strain of porcine reproductive and respiratory syndrome virus. Virology. 2012; 435(2):372-84. PMC: 7111980. DOI: 10.1016/j.virol.2012.09.013. View

Greten F, Grivennikov S . Inflammation and Cancer: Triggers, Mechanisms, and Consequences. Immunity. 2019; 51(1):27-41. PMC: 6831096. DOI: 10.1016/j.immuni.2019.06.025. View

Zhao H, Wu L, Yan G, Chen Y, Zhou M, Wu Y . Inflammation and tumor progression: signaling pathways and targeted intervention. Signal Transduct Target Ther. 2021; 6(1):263. PMC: 8273155. DOI: 10.1038/s41392-021-00658-5. View

Schafer M, Werner S . Cancer as an overhealing wound: an old hypothesis revisited. Nat Rev Mol Cell Biol. 2008; 9(8):628-38. DOI: 10.1038/nrm2455. View

Cai J, Harrison A, Zheng Y, Yan K, Huo Y, Xiao J . Lesion-Harvester: Iteratively Mining Unlabeled Lesions and Hard-Negative Examples at Scale. IEEE Trans Med Imaging. 2020; 40(1):59-70. DOI: 10.1109/TMI.2020.3022034. View

Huang H, Wang Y, Kandpal M, Zhao G, Cardenas H, Ji Y . FTO-Dependent -Methyladenosine Modifications Inhibit Ovarian Cancer Stem Cell Self-Renewal by Blocking cAMP Signaling. Cancer Res. 2020; 80(16):3200-3214. PMC: 7442742. DOI: 10.1158/0008-5472.CAN-19-4044. View

De Marzo A, Platz E, Sutcliffe S, Xu J, Gronberg H, Drake C . Inflammation in prostate carcinogenesis. Nat Rev Cancer. 2007; 7(4):256-69. PMC: 3552388. DOI: 10.1038/nrc2090. View

Nishi K, Luo H, Ishikura S, Doi K, Iwaihara Y, Wills L . Apremilast Induces Apoptosis of Human Colorectal Cancer Cells with Mutant . Anticancer Res. 2017; 37(7):3833-3839. DOI: 10.21873/anticanres.11762. View

Fortin M, Danjou H, Higgins M, Gougeon J, Aube P, Moktefi K . A multi-target antisense approach against PDE4 and PDE7 reduces smoke-induced lung inflammation in mice. Respir Res. 2009; 10:39. PMC: 2696437. DOI: 10.1186/1465-9921-10-39. View

10.

Ariffin H, Azanan M, Abd Ghafar S, Oh L, Lau K, Thirunavakarasu T . Young adult survivors of childhood acute lymphoblastic leukemia show evidence of chronic inflammation and cellular aging. Cancer. 2017; 123(21):4207-4214. DOI: 10.1002/cncr.30857. View

11.

Kachuri L, Johansson M, Rashkin S, Graff R, Bosse Y, Manem V . Immune-mediated genetic pathways resulting in pulmonary function impairment increase lung cancer susceptibility. Nat Commun. 2020; 11(1):27. PMC: 6946810. DOI: 10.1038/s41467-019-13855-2. View

12.

Ahlstrom M, Pekkinen M, Huttunen M, Lamberg-Allardt C . Dexamethasone down-regulates cAMP-phosphodiesterase in human osteosarcoma cells. Biochem Pharmacol. 2005; 69(2):267-75. DOI: 10.1016/j.bcp.2004.09.012. View

13.

Rickles R, Pierce L, Giordano 3rd T, Tam W, McMillin D, Delmore J . Adenosine A2A receptor agonists and PDE inhibitors: a synergistic multitarget mechanism discovered through systematic combination screening in B-cell malignancies. Blood. 2010; 116(4):593-602. DOI: 10.1182/blood-2009-11-252668. View

14.

Schick M, Schlegel N . Clinical Implication of Phosphodiesterase-4-Inhibition. Int J Mol Sci. 2022; 23(3). PMC: 8835523. DOI: 10.3390/ijms23031209. View

15.

Hoddah H, Marcantoni A, Comunanza V, Carabelli V, Carbone E . L-type channel inhibition by CB1 cannabinoid receptors is mediated by PTX-sensitive G proteins and cAMP/PKA in GT1-7 hypothalamic neurons. Cell Calcium. 2009; 46(5-6):303-12. DOI: 10.1016/j.ceca.2009.08.007. View

16.

Sengupta R, Zaidi S . : Discovery Science Driving Clinical Breakthroughs. Clin Cancer Res. 2021; 27(21):5757-5759. DOI: 10.1158/1078-0432.CCR-21-3367. View

17.

Biller L, Schrag D . Diagnosis and Treatment of Metastatic Colorectal Cancer: A Review. JAMA. 2021; 325(7):669-685. DOI: 10.1001/jama.2021.0106. View

18.

Campbell S, van Groen T, Kadish I, Smoot L, Bolger G . Altered phosphorylation, electrophysiology, and behavior on attenuation of PDE4B action in hippocampus. BMC Neurosci. 2017; 18(1):77. PMC: 5712142. DOI: 10.1186/s12868-017-0396-6. View

19.

Bender A, Beavo J . Cyclic nucleotide phosphodiesterases: molecular regulation to clinical use. Pharmacol Rev. 2006; 58(3):488-520. DOI: 10.1124/pr.58.3.5. View

20.

Hsien Lai S, Zervoudakis G, Chou J, Gurney M, Quesnelle K . PDE4 subtypes in cancer. Oncogene. 2020; 39(19):3791-3802. PMC: 7444459. DOI: 10.1038/s41388-020-1258-8. View