Biological Roles of Adenine Methylation in RNA

Overview

Journal Nat Rev Genet

Specialty Genetics

Date 2022 Oct 19

PMID 36261710

Authors

Konstantinos Boulias

Eric Lieberman Greer

Affiliations

Soon will be listed here.

Abstract

N-Methyladenosine (mA) is one of the most abundant modifications of the epitranscriptome and is found in cellular RNAs across all kingdoms of life. Advances in detection and mapping methods have improved our understanding of the effects of mA on mRNA fate and ribosomal RNA function, and have uncovered novel functional roles in virtually every species of RNA. In this Review, we explore the latest studies revealing roles for mA-modified RNAs in chromatin architecture, transcriptional regulation and genome stability. We also summarize mA functions in biological processes such as stem-cell renewal and differentiation, brain function, immunity and cancer progression.

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