A Single Short Reprogramming Early in Life Initiates and Propagates an Epigenetically Related Mechanism Improving Fitness and Promoting an Increased Healthy Lifespan

Overview

Journal Aging Cell

Specialties Cell Biology
Geriatrics

Date 2022 Oct 17

PMID 36251933

Authors

Quentin Alle

Enora Le Borgne

Paul Bensadoun

Camille Lemey

Nelly Bechir

Melissa Gabanou

Fanny Estermann

Christelle Bertrand-Gaday

Laurence Pessemesse

Karine Toupet

Romain Desprat

Jerome Vialaret

Christophe Hirtz

Daniele Noel

Christian Jorgensen

Francois Casas

Ollivier Milhavet

Jean-Marc Lemaitre

Affiliations

Soon will be listed here.

Abstract

Recent advances in cell reprogramming showed that OSKM induction is able to improve cell physiology in vitro and in vivo. Here, we show that a single short reprogramming induction is sufficient to prevent musculoskeletal functions deterioration of mice, when applied in early life. In addition, in old age, treated mice have improved tissue structures in kidney, spleen, skin, and lung, with an increased lifespan of 15% associated with organ-specific differential age-related DNA methylation signatures rejuvenated by the treatment. Altogether, our results indicate that a single short reprogramming early in life might initiate and propagate an epigenetically related mechanism to promote a healthy lifespan.

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