Radiation Dose Rate Effects: What is New and What is Needed?

Overview

Journal Radiat Environ Biophys

Specialties Biophysics
Environmental Health
Oncology
Radiology

Date 2022 Oct 14

PMID 36241855

Authors

Donna Lowe

Laurence Roy

Maria Antonella Tabocchini

Werner Ruhm

Richard Wakeford

Gayle E Woloschak

Dominique Laurier

Affiliations

Soon will be listed here.

Abstract

Despite decades of research to understand the biological effects of ionising radiation, there is still much uncertainty over the role of dose rate. Motivated by a virtual workshop on the "Effects of spatial and temporal variation in dose delivery" organised in November 2020 by the Multidisciplinary Low Dose Initiative (MELODI), here, we review studies to date exploring dose rate effects, highlighting significant findings, recent advances and to provide perspective and recommendations for requirements and direction of future work. A comprehensive range of studies is considered, including molecular, cellular, animal, and human studies, with a focus on low linear-energy-transfer radiation exposure. Limits and advantages of each type of study are discussed, and a focus is made on future research needs.

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