The JAK-STAT Pathway at 30: Much Learned, Much More to Do

Overview

Journal Cell

Publisher Cell Press

Specialty Cell Biology

Date 2022 Oct 14

PMID 36240739

Authors

Rachael L Philips

Yuxin Wang

HyeonJoo Cheon

Yuka Kanno

Massimo Gadina

Vittorio Sartorelli

Curt M Horvath

James E Darnell Jr

George R Stark

John J OShea

Affiliations

Soon will be listed here.

Abstract

The discovery of the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway arose from investigations of how cells respond to interferons (IFNs), revealing a paradigm in cell signaling conserved from slime molds to mammals. These discoveries revealed mechanisms underlying rapid gene expression mediated by a wide variety of extracellular polypeptides including cytokines, interleukins, and related factors. This knowledge has provided numerous insights into human disease, from immune deficiencies to cancer, and was rapidly translated to new drugs for autoimmune, allergic, and infectious diseases, including COVID-19. Despite these advances, major challenges and opportunities remain.

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