Vittorio Sartorelli
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Explore the profile of Vittorio Sartorelli including associated specialties, affiliations and a list of published articles.
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94
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6727
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Recent Articles
1.
Fedkenheuer M, Shang Y, Jung S, Fedkenheuer K, Park S, Mazza D, et al.
Nat Commun
. 2025 Jan;
16(1):843.
PMID: 39833168
Cells undergo tens of thousands of DNA-damaging events each day. Defects in repairing double-stranded breaks (DSBs) can lead to genomic instability, contributing to cancer, genetic disorders, immunological diseases, and developmental...
2.
Sartorelli V, Ciuffoli V
Genes Dev
. 2024 Dec;
39(3-4):186-208.
PMID: 39662967
Adult stem cells maintain homeostasis and enable regeneration of most tissues. Quiescence, proliferation, and differentiation of stem cells and their progenitors are tightly regulated processes governed by dynamic transcriptional, epigenetic,...
3.
Trzaskoma P, Jung S, Pekowska A, Bohrer C, Wang X, Naz F, et al.
Sci Adv
. 2024 Aug;
10(32):eadl4893.
PMID: 39121214
Discontinuous transcription is evolutionarily conserved and a fundamental feature of gene regulation; yet, the exact mechanisms underlying transcriptional bursting are unresolved. Analyses of bursting transcriptome-wide have focused on the role...
4.
Ko K, Sartorelli V
STAR Protoc
. 2024 May;
5(2):103067.
PMID: 38748883
Single-cell RNA sequencing (scRNA-seq) provides high resolution of cell-to-cell variation in gene expression and offers insights into cell heterogeneity, differentiating dynamics, and disease mechanisms. However, technical challenges such as low...
5.
Mozzetta C, Sartorelli V, Steinkuhler C, Puri P
Trends Mol Med
. 2024 Apr;
30(7):698.
PMID: 38643051
No abstract available.
6.
Ciuffoli V, Feng X, Jiang K, Acevedo-Luna N, Ko K, Wang A, et al.
Genes Dev
. 2024 Mar;
38(3-4):151-167.
PMID: 38453480
By satisfying bioenergetic demands, generating biomass, and providing metabolites serving as cofactors for chromatin modifiers, metabolism regulates adult stem cell biology. Here, we report that a branch of glycolysis, the...
7.
Mozzetta C, Sartorelli V, Steinkuhler C, Puri P
Trends Mol Med
. 2024 Feb;
30(3):278-294.
PMID: 38408879
Earlier evidence that targeting the balance between histone acetyltransferases (HATs) and deacetylases (HDACs), through exposure to HDAC inhibitors (HDACis), could enhance skeletal myogenesis, prompted interest in using HDACis to promote...
8.
Ko K, Sartorelli V
iScience
. 2024 Feb;
27(3):109027.
PMID: 38361616
By providing high-resolution of cell-to-cell variation in gene expression, single-cell RNA sequencing (scRNA-seq) offers insights into cell heterogeneity, differentiating dynamics, and disease mechanisms. However, challenges such as low capture rates...
9.
Ko K, Jiang K, DellOrso S, Sartorelli V
STAR Protoc
. 2023 May;
4(2):102307.
PMID: 37192048
Here, we present workflows for integrating independent transcriptomic and chromatin accessibility datasets and analyzing multiomics. First, we describe steps for integrating independent transcriptomic and chromatin accessibility measurements. Next, we detail...
10.
Feng X, Wang A, Juan A, Ko K, Jiang K, Riparini G, et al.
Dev Cell
. 2023 Apr;
58(12):1052-1070.e10.
PMID: 37105173
Organismal homeostasis and regeneration are predicated on committed stem cells that can reside for long periods in a mitotically dormant but reversible cell-cycle arrest state defined as quiescence. Premature escape...