Intraventricular Hemorrhage Prediction in Premature Neonates in the Era of Hemodynamics Monitoring: a Prospective Cohort Study

Overview

Journal Eur J Pediatr

Specialty Pediatrics

Date 2022 Sep 28

PMID 36171508

Authors

Marwa Mohamed Farag

Mohamed Hazem Gouda

Ali Mohamed Abd Almohsen

Mohammed Attia Khalifa

Affiliations

Soon will be listed here.

Abstract

Conclusions: There are strong relations between both low SVCF and high ACA-RI, and IVH development in premature neonates ≤ 32 weeks and birth weight ≤ 1500 g, with more significance towards catastrophic IVH. Admission RSS and LVO are the strongest factors affecting SVCF. Maternal anemia, patent ductus arteriosus size (mm/kg), and capillary refill time were significantly associated with high ACA-RI. These findings help in more understanding of pathophysiological factors affecting central perfusion that might affect the longer term neurodeveopmental outcome.

Trial Registration: This work was registered in clinical trial.gv no NCT05050032.

What Is Known: •Whether SVCF and RI-ACA can predict IVH in preterm neonates is still debatable.

What Is New: •Low SVC flow and high ACA-RI significantly increased risk of IVH, confirming the role of hypoperfusion-reperfusion cycle in IVH development. The most striking result that combined metrics using the cut-off value of < 41 ml/kg/min for SVCF and > 0.85 for ACA-RI "in the first day of life" can correctly reject the presence of IVH in 98% of patients "during the first week of life."

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