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The Early Hematological Profile and Its Variations: A Useful Tool in the Prediction of Intraventricular Hemorrhage in Extremely Preterm Infants

Overview
Publisher MDPI
Specialty General Medicine
Date 2024 Mar 28
PMID 38541136
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Abstract

: The purpose of this study to investigate if the early variations in the hematological profile could be a useful tool in the prediction and evaluation of intraventricular hemorrhage. : It is a retrospective study conducted between 1 January 2017 and 31 December 2022, in a tertiary academic center. In-born infants ≤ 28 weeks of gestation ( = 134) were enrolled. The study group of infants with all grades of IVH was further divided into mild IVH subgroups (grades 1 and 2) and severe IVH subgroups (grades 3 and 4); the control group included infants without IVH. : The prevalence of IVH was 35.8% ( = 48 of 134 infants-study group). We identified significantly lower median values of HGB ( = 0.0312) and HCT ( = 0.0172) in all grades of the IVH group at birth as compared with control, followed by a significantly higher drop in MCV ( = 0.0146) and MCH ( = 0.0002) in the fourth day of life. : Extremely preterm infants with IVH may have lower HTC and HGB values at birth, together with a decrease in MCH and MCHC and increase in MPV. The predictive model based on logistic regression analysis could predict the probability of the occurrence of IVH according to their values.

References
1.
Hosono S, Mugishima H, Kitamura T, Inami I, Fujita H, Hosono A . Effect of hemoglobin on transfusion and neonatal adaptation in extremely low-birthweight infants. Pediatr Int. 2008; 50(3):306-11. DOI: 10.1111/j.1442-200X.2008.02586.x. View

2.
Strauss R, Mock D, Johnson K, Cress G, Burmeister L, Zimmerman M . A randomized clinical trial comparing immediate versus delayed clamping of the umbilical cord in preterm infants: short-term clinical and laboratory endpoints. Transfusion. 2008; 48(4):658-65. PMC: 2883857. DOI: 10.1111/j.1537-2995.2007.01589.x. View

3.
Ochoa J, Contreras-Chova F, Munoz S, Araujo-Nepomuceno E, Bonillo A, Molina-Carballo A . Fluidity and oxidative stress in erythrocytes from very low birth weight infants during their first 7 days of life. Free Radic Res. 2007; 41(9):1035-40. DOI: 10.1080/10715760701549556. View

4.
Zhu Z, Yuan L, Wang J, Li Q, Yang C, Gao X . Mortality and Morbidity of Infants Born Extremely Preterm at Tertiary Medical Centers in China From 2010 to 2019. JAMA Netw Open. 2021; 4(5):e219382. PMC: 8114138. DOI: 10.1001/jamanetworkopen.2021.9382. View

5.
Saygili Karagol B, Calisici E, Zeybek C, Unay B, Yuksel S . The impact of initial hematocrit values after birth on peri-/intraventricular hemorrhage in extremely low birth weight neonates. Childs Nerv Syst. 2021; 38(1):109-114. DOI: 10.1007/s00381-021-05398-z. View