Suppresses High-Fat Diet-Induced Obesity and Related Metabolic Disorders in Beagles

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2022 Sep 23

PMID 36144806

Authors

Xiao-Qi Lin

Wei Chen

Ke Ma

Zhen-Zhen Liu

Yu Gao

Jian-Gang Zhang

Tao Wang

Yong-Jun Yang

Affiliations

Soon will be listed here.

Abstract

Obesity is one of the prevalent chronic diseases in human and companion animals usually associated with several metabolic disorders. The gut commensal bacterium () is known for its therapeutic effects on metabolic disorders and inflammations. Here, we isolated the AKK2 strain from the feces of interferon-inducible protein 204 (IFI204) mice and further evaluated its anti-obesity effects on high-fat diet (HFD)-fed C57BL/6J mice and beagles. The results showed that it effectively controlled weight gain. Microbiome analysis using 16S rRNA gene sequencing revealed that HFD alters gut microbiota composition and AKK2 increases the (F/B) ratio in beagles. Furthermore, we prepared microcapsules containing AKK2, and tolerance tests showed the encapsulation maintained high viability and stability in an aerobic environment and simulated the secretion of gastrointestinal fluids. Overall, this study widens the spectrum of applications to prevent obesity.

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