Evaluation of a New Echocardiographic Tool for Cardiac Output Monitoring: An Experimental Study on A Controlled Hemorrhagic Shock Model in Anesthetized Piglets

Overview

Journal J Clin Med

Specialty General Medicine

Date 2022 Sep 23

PMID 36143066

Authors

Thibaut Markarian

Laura Grau-Mercier

Celine Occelli

Florian Ajavon

Pierre-Geraud Claret

Fabien Coisy

Xavier Bobbia

Affiliations

Soon will be listed here.

Abstract

Background: Cardiac output (CO) monitoring is recommended in patients with shock. The search for a reliable, rapid, and noninvasive tool is necessary for clinical practice. A new echocardiographic CO flow index (COF) is the automatic calculation of the sub-aortic VTI multiplied by the automatic calculation of the heart rate (HR). The primary objective of this study was to show the correlation between COF and CO measured by thermodilution (COth) in a controlled hemorrhagic shock model in anesthetized piglets. Secondary objectives were to show the correlation between COth and CO calculated from left outflow tract (LVOT) measurement and manual VTI (COman), and CO measured by LVOT measurement and VTIauto (COauto).

Methods: Prospective interventional experimental study. In seventeen ventilated and anesthetized piglets, a state of hemorrhagic shock was induced, maintained, then resuscitated and stabilized. The gold standard for CO and stroke volume measurement was thermodilution (COth).

Results: 191 measurements were performed. The correlation coefficients (r) between COth and COF, COman, and COauto were 0.73 [0.62; 0.81], 0.66 [0.56; 0.74], and 0.73 [0.63; 0.81], respectively.

Conclusions: In this study, the COF appears to have a strong correlation to the COth. This automatic index, which takes into account the HR and does not require the measurement of LVOT, could be a rapidly obtained index in clinical practice.

Citing Articles

Association between speckle tracking echocardiography and pressure-volume loops during cardiogenic shock development.

Frederiksen P, Linde L, Gregers E, Udesen N, Helgestad O, Banke A Open Heart. 2024; 11(1).

PMID: 38782543 PMC: 11116883. DOI: 10.1136/openhrt-2023-002512.

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