Global Longitudinal Strain Changes During Hemorrhagic Shock: An Experimental Study

Overview

Journal Turk J Emerg Med

Specialty Emergency Medicine

Date 2020 Aug 25

PMID 32832728

Citations 1

Authors

Laurent Zieleskiewicz

Pierre-Geraud Claret

Laurent Muller

Jean Emmanuel de La Coussaye

Jean Yves Lefrant

Iris Schuster

Claire Roger

Xavier Bobbia

Affiliations

Soon will be listed here.

Abstract

Objectives: Global longitudinal strain (GLS) appears sensitive and reproducible to identify left ventricular systolic dysfunction. The main objective was to analyze the GLS changes in an anesthetized-piglet model of controlled hemorrhagic shock (HS). The secondary objective was to evaluate if GLS changes was different depending on the expansion fluid treatment with or without norepinephrine.

Methods: Eighteen anesthetized and ventilated piglets were bled until the mean arterial pressure reached 40 mmHg. Controlled hemorrhage was maintained for 30 min before randomizing the piglets to three resuscitation groups: control group, LR group (resuscitated with lactated ringer), and NA group (resuscitated with lactated ringer and norepinephrine).

Results: There was no difference in the baseline hemodynamic, biological, and ultrasound data among the three groups. During the hemorrhagic phase, the GLS increased significantly from 25 mL/kg of depletion. During the resuscitation phase, the GLS decreased significantly from 20 mL/kg of fluid administration. There was no difference in GLS variation among the groups during the hemorrhagic, maintenance, and resuscitation phases.

Conclusion: In our HS model, GLS increased with hemorrhage and decreased during resuscitation, showing its preload dependence.

Citing Articles

Evaluation of a New Echocardiographic Tool for Cardiac Output Monitoring: An Experimental Study on A Controlled Hemorrhagic Shock Model in Anesthetized Piglets.

Markarian T, Grau-Mercier L, Occelli C, Ajavon F, Claret P, Coisy F J Clin Med. 2022; 11(18).

PMID: 36143066 PMC: 9503332. DOI: 10.3390/jcm11185420.

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