Bioinspired Flexible Electronics for Seamless Neural Interfacing and Chronic Recording

Overview

Journal Nanoscale Adv

Publisher Royal Society of Chemistry

Specialty Biotechnology

Date 2022 Sep 22

PMID 36134275

Authors

Hongbian Li

Jinfen Wang

Ying Fang

Affiliations

Soon will be listed here.

Abstract

Implantable neural probes are among the most widely applied tools for the understanding of neural circuit functions and the treatment of neurological disorders. Despite remarkable progress in recent years, it is still challenging for conventional rigid probes to achieve stable neural recording over long periods of time. Recently, flexible electronics with biomimetic structures and mechanical properties have been demonstrated for the formation of seamless probe-neural interfaces, enabling long-term recording stability. In this review, we provide an overview of bioinspired flexible electronics, from their structural design to probe-brain interfaces and chronic neural recording applications. Opportunities of bioinspired flexible electronics in fundamental neuroscience and clinical studies are also discussed.

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References

Vitale F, Summerson S, Aazhang B, Kemere C, Pasquali M . Neural stimulation and recording with bidirectional, soft carbon nanotube fiber microelectrodes. ACS Nano. 2015; 9(4):4465-74. DOI: 10.1021/acsnano.5b01060. View

Jun J, Steinmetz N, Siegle J, Denman D, Bauza M, Barbarits B . Fully integrated silicon probes for high-density recording of neural activity. Nature. 2017; 551(7679):232-236. PMC: 5955206. DOI: 10.1038/nature24636. View

Du Z, Kolarcik C, Kozai T, Luebben S, Sapp S, Zheng X . Ultrasoft microwire neural electrodes improve chronic tissue integration. Acta Biomater. 2017; 53:46-58. PMC: 5512864. DOI: 10.1016/j.actbio.2017.02.010. View

Khodagholy D, Gelinas J, Buzsaki G . Learning-enhanced coupling between ripple oscillations in association cortices and hippocampus. Science. 2017; 358(6361):369-372. PMC: 5872145. DOI: 10.1126/science.aan6203. View

Hubel D . Tungsten Microelectrode for Recording from Single Units. Science. 1957; 125(3247):549-50. DOI: 10.1126/science.125.3247.549. View

Patel P, Zhang H, Robbins M, Nofar J, Marshall S, Kobylarek M . Chronic in vivo stability assessment of carbon fiber microelectrode arrays. J Neural Eng. 2016; 13(6):066002. PMC: 5118062. DOI: 10.1088/1741-2560/13/6/066002. View

Du M, Guan S, Gao L, Lv S, Yang S, Shi J . Flexible Micropillar Electrode Arrays for In Vivo Neural Activity Recordings. Small. 2019; 15(20):e1900582. DOI: 10.1002/smll.201900582. View

Guan S, Wang J, Gu X, Zhao Y, Hou R, Fan H . Elastocapillary self-assembled neurotassels for stable neural activity recordings. Sci Adv. 2019; 5(3):eaav2842. PMC: 6436924. DOI: 10.1126/sciadv.aav2842. View

Cohen-Karni T, Qing Q, Li Q, Fang Y, Lieber C . Graphene and nanowire transistors for cellular interfaces and electrical recording. Nano Lett. 2010; 10(3):1098-102. PMC: 2899684. DOI: 10.1021/nl1002608. View

10.

Guitchounts G, Markowitz J, Liberti W, Gardner T . A carbon-fiber electrode array for long-term neural recording. J Neural Eng. 2013; 10(4):046016. PMC: 3875136. DOI: 10.1088/1741-2560/10/4/046016. View

11.

Kratochvil M, Seymour A, Li T, Pasca S, Kuo C, Heilshorn S . Engineered materials for organoid systems. Nat Rev Mater. 2021; 4(9):606-622. PMC: 7864216. DOI: 10.1038/s41578-019-0129-9. View

12.

Hong G, Fu T, Zhou T, Schuhmann T, Huang J, Lieber C . Syringe Injectable Electronics: Precise Targeted Delivery with Quantitative Input/Output Connectivity. Nano Lett. 2015; 15(10):6979-84. DOI: 10.1021/acs.nanolett.5b02987. View

13.

Biran R, Martin D, Tresco P . Neuronal cell loss accompanies the brain tissue response to chronically implanted silicon microelectrode arrays. Exp Neurol. 2005; 195(1):115-26. DOI: 10.1016/j.expneurol.2005.04.020. View

14.

Wei X, Luan L, Zhao Z, Li X, Zhu H, Potnis O . Nanofabricated Ultraflexible Electrode Arrays for High-Density Intracortical Recording. Adv Sci (Weinh). 2018; 5(6):1700625. PMC: 6010728. DOI: 10.1002/advs.201700625. View

15.

Yoon I, Hamaguchi K, V Borzenets I, Finkelstein G, Mooney R, Donald B . Intracellular Neural Recording with Pure Carbon Nanotube Probes. PLoS One. 2013; 8(6):e65715. PMC: 3686779. DOI: 10.1371/journal.pone.0065715. View

16.

McCallum G, Sui X, Qiu C, Marmerstein J, Zheng Y, Eggers T . Chronic interfacing with the autonomic nervous system using carbon nanotube (CNT) yarn electrodes. Sci Rep. 2017; 7(1):11723. PMC: 5601469. DOI: 10.1038/s41598-017-10639-w. View

17.

Vitale F, Vercosa D, Rodriguez A, Pamulapati S, Seibt F, Lewis E . Fluidic Microactuation of Flexible Electrodes for Neural Recording. Nano Lett. 2017; 18(1):326-335. PMC: 6632092. DOI: 10.1021/acs.nanolett.7b04184. View

18.

Rousche P, Normann R . Chronic recording capability of the Utah Intracortical Electrode Array in cat sensory cortex. J Neurosci Methods. 1999; 82(1):1-15. DOI: 10.1016/s0165-0270(98)00031-4. View

19.

Schuhmann Jr T, Yao J, Hong G, Fu T, Lieber C . Syringe-Injectable Electronics with a Plug-and-Play Input/Output Interface. Nano Lett. 2017; 17(9):5836-5842. DOI: 10.1021/acs.nanolett.7b03081. View

20.

Cools J, Jin Q, Yoon E, Burbano D, Luo Z, Cuypers D . A Micropatterned Multielectrode Shell for 3D Spatiotemporal Recording from Live Cells. Adv Sci (Weinh). 2018; 5(4):1700731. PMC: 5908352. DOI: 10.1002/advs.201700731. View