Perivascular Macrophages in the CNS: From Health to Neurovascular Diseases

Overview

Journal CNS Neurosci Ther

Specialties Neurology
Pharmacology

Date 2022 Sep 21

PMID 36128654

Authors

Li Zheng

Yunlu Guo

Xiaozhu Zhai

Yueman Zhang

Weijie Chen

Ziyu Zhu

Wei Xuan

Peiying Li

Affiliations

Soon will be listed here.

Abstract

Brain perivascular macrophages (PVMs) are attracting increasing attention as this emerging cell population in the brain has multifaced roles in supporting the central nervous system structure, brain development, and maintaining physiological functions. They also widely participate in neurological diseases such as neurodegeneration and ischemic stroke. Moreover, PVMs have been reported to have both beneficial and detrimental effects under different pathological contexts. Advanced research technologies allowed the further in-depth study of PVMs and revealed novel concepts in their origins, differentiation, and regulatory mechanisms. Deepened understanding of the roles of PVMs in different brain pathological conditions can reveal novel phenotypic changes and regulatory signaling, which might pave the way for the development of novel treatment strategies targeting PVMs.

Citing Articles

All Three Supersystems-Nervous, Vascular, and Immune-Contribute to the Cortical Infarcts After Subarachnoid Hemorrhage.

Dreier J, Joerk A, Uchikawa H, Horst V, Lemale C, Radbruch H Transl Stroke Res. 2024; 16(1):96-118.

PMID: 38689162 PMC: 11772491. DOI: 10.1007/s12975-024-01242-z.

The Association between Glymphatic System and Perivascular Macrophages in Brain Waste Clearance.

Kaur J, Boyd E, Ding G, Zhang L, Luo H, Li Q Diagnostics (Basel). 2024; 14(7).

PMID: 38611644 PMC: 11011895. DOI: 10.3390/diagnostics14070731.

Roles of Macrophages and Endothelial Cells and Their Crosstalk in Acute Lung Injury.

Osorio-Valencia S, Zhou B Biomedicines. 2024; 12(3).

PMID: 38540245 PMC: 10968255. DOI: 10.3390/biomedicines12030632.

Susceptibility of perivenous macrophages to PRRSV-1 subtype 1 LV and PRRSV-1 subtype 3 Lena using a new vein explant model.

Han S, Oh D, Xie J, Nauwynck H Front Cell Infect Microbiol. 2023; 13:1223530.

PMID: 37554354 PMC: 10406384. DOI: 10.3389/fcimb.2023.1223530.

Pretreatment with Clodronate Improved Neurological Function by Preventing Reduction of Posthemorrhagic Cerebral Blood Flow in Experimental Subarachnoid Hemorrhage.

Uchikawa H, Kameno K, Kai K, Kajiwara S, Fujimori K, Uekawa K Neurocrit Care. 2023; 39(1):207-217.

PMID: 37308726 DOI: 10.1007/s12028-023-01754-w.

References

Silva H, Kitoko J, Queiroz C, Kroehling L, Matheis F, Yang K . c-MAF-dependent perivascular macrophages regulate diet-induced metabolic syndrome. Sci Immunol. 2021; 6(64):eabg7506. DOI: 10.1126/sciimmunol.abg7506. View

. Expression of Concern: Blockade of Fas signaling in breast cancer cells suppresses tumor growth and metastasis via disruption of Fas signaling-initiated cancer-related inflammation. J Biol Chem. 2020; 295(26):8886. PMC: 7324494. DOI: 10.1074/jbc.EC120.014573. View

Lim H, Lim S, Tan C, Thiam C, Goh C, Carbajo D . Hyaluronan Receptor LYVE-1-Expressing Macrophages Maintain Arterial Tone through Hyaluronan-Mediated Regulation of Smooth Muscle Cell Collagen. Immunity. 2018; 49(2):326-341.e7. DOI: 10.1016/j.immuni.2018.06.008. View

Iadecola C, Zhang F, Niwa K, Eckman C, Turner S, FISCHER E . SOD1 rescues cerebral endothelial dysfunction in mice overexpressing amyloid precursor protein. Nat Neurosci. 1999; 2(2):157-61. DOI: 10.1038/5715. View

Albargothy N, Johnston D, MacGregor-Sharp M, Weller R, Verma A, Hawkes C . Convective influx/glymphatic system: tracers injected into the CSF enter and leave the brain along separate periarterial basement membrane pathways. Acta Neuropathol. 2018; 136(1):139-152. PMC: 6015107. DOI: 10.1007/s00401-018-1862-7. View

Villa A, Vegeto E, Poletti A, Maggi A . Estrogens, Neuroinflammation, and Neurodegeneration. Endocr Rev. 2016; 37(4):372-402. PMC: 4971309. DOI: 10.1210/er.2016-1007. View

Dissing-Olesen L, Hong S, Stevens B . New Brain Lymphatic Vessels Drain Old Concepts. EBioMedicine. 2015; 2(8):776-7. PMC: 4563157. DOI: 10.1016/j.ebiom.2015.08.019. View

Abbott N . Astrocyte-endothelial interactions and blood-brain barrier permeability. J Anat. 2002; 200(6):629-38. PMC: 1570746. DOI: 10.1046/j.1469-7580.2002.00064.x. View

Tenen D, Hromas R, Licht J, Zhang D . Transcription factors, normal myeloid development, and leukemia. Blood. 1997; 90(2):489-519. View

10.

Scott E, Simon M, Anastasi J, Singh H . Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages. Science. 1994; 265(5178):1573-7. DOI: 10.1126/science.8079170. View

11.

Kaminski M, Bechmann I, Kiwit J, Glumm J . Migration of monocytes after intracerebral injection. Cell Adh Migr. 2012; 6(3):164-7. PMC: 3427229. DOI: 10.4161/cam.20281. View

12.

Willis C, Garwood C, Ray D . A size selective vascular barrier in the rat area postrema formed by perivascular macrophages and the extracellular matrix. Neuroscience. 2007; 150(2):498-509. DOI: 10.1016/j.neuroscience.2007.09.023. View

13.

Nguyen L, Ma D, Shui G, Wong P, Cazenave-Gassiot A, Zhang X . Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid. Nature. 2014; 509(7501):503-6. DOI: 10.1038/nature13241. View

14.

Kurz C, Walker L, Rauchmann B, Perneczky R . Dysfunction of the blood-brain barrier in Alzheimer's disease: Evidence from human studies. Neuropathol Appl Neurobiol. 2021; 48(3):e12782. DOI: 10.1111/nan.12782. View

15.

Aguzzi A, Barres B, Bennett M . Microglia: scapegoat, saboteur, or something else?. Science. 2013; 339(6116):156-61. PMC: 4431634. DOI: 10.1126/science.1227901. View

16.

Thanopoulou K, Fragkouli A, Stylianopoulou F, Georgopoulos S . Scavenger receptor class B type I (SR-BI) regulates perivascular macrophages and modifies amyloid pathology in an Alzheimer mouse model. Proc Natl Acad Sci U S A. 2010; 107(48):20816-21. PMC: 2996412. DOI: 10.1073/pnas.1005888107. View

17.

Koizumi T, Kerkhofs D, Mizuno T, Steinbusch H, Foulquier S . Vessel-Associated Immune Cells in Cerebrovascular Diseases: From Perivascular Macrophages to Vessel-Associated Microglia. Front Neurosci. 2019; 13:1291. PMC: 6904330. DOI: 10.3389/fnins.2019.01291. View

18.

Clark J, Sharp F . Bilirubin oxidation products (BOXes) and their role in cerebral vasospasm after subarachnoid hemorrhage. J Cereb Blood Flow Metab. 2006; 26(10):1223-33. DOI: 10.1038/sj.jcbfm.9600280. View

19.

Holness C, Simmons D . Molecular cloning of CD68, a human macrophage marker related to lysosomal glycoproteins. Blood. 1993; 81(6):1607-13. View

20.

Hammond T, Dufort C, Dissing-Olesen L, Giera S, Young A, Wysoker A . Single-Cell RNA Sequencing of Microglia throughout the Mouse Lifespan and in the Injured Brain Reveals Complex Cell-State Changes. Immunity. 2018; 50(1):253-271.e6. PMC: 6655561. DOI: 10.1016/j.immuni.2018.11.004. View