Strategies to Safely Target Widely Expressed Soluble Adenylyl Cyclase for Contraception

Overview

Journal Front Pharmacol

Date 2022 Sep 12

PMID 36091839

Authors

Jacob Ferreira

Lonny R Levin

Jochen Buck

Affiliations

Soon will be listed here.

Abstract

In humans, the prototypical second messenger cyclic AMP is produced by 10 adenylyl cyclase isoforms, which are divided into two classes. Nine isoforms are G protein coupled transmembrane adenylyl cyclases (tmACs; ADCY1-9) and the 10th is the bicarbonate regulated soluble adenylyl cyclase (sAC; ADCY10). This review details why sAC is uniquely druggable and outlines ways to target sAC for novel forms of male and female contraception.

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