Cyclic Nucleotide-regulated Cation Channels

Overview

Journal J Biol Chem

Specialty Biochemistry

Date 2008 Dec 5

PMID 19054768

Citations 47

Authors

Martin Biel

Affiliations

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Abstract

Cyclic nucleotide-regulated cation channels are ion channels whose activation is regulated by the direct binding of cAMP or cGMP to the channel protein. Two structurally related families of channels regulated by cyclic nucleotides have been identified, the cyclic nucleotide-gated channels and the hyperpolarization-activated cyclic nucleotide-gated channels. Cyclic nucleotide-gated channels play a key role in visual and olfactory transduction. Hyperpolarization-activated cyclic nucleotide-gated channels are present in the conduction system of the heart and are involved in the control of cardiac automaticity. Moreover, these channels are widely expressed in central and peripheral neurons, where they control a variety of fundamental processes.

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References

Kaupp U, Seifert R . Cyclic nucleotide-gated ion channels. Physiol Rev. 2002; 82(3):769-824. DOI: 10.1152/physrev.00008.2002. View

Nolan M, Malleret G, Dudman J, Buhl D, Santoro B, Gibbs E . A behavioral role for dendritic integration: HCN1 channels constrain spatial memory and plasticity at inputs to distal dendrites of CA1 pyramidal neurons. Cell. 2004; 119(5):719-32. DOI: 10.1016/j.cell.2004.11.020. View

Biel M, Seeliger M, Pfeifer A, Kohler K, Gerstner A, Ludwig A . Selective loss of cone function in mice lacking the cyclic nucleotide-gated channel CNG3. Proc Natl Acad Sci U S A. 1999; 96(13):7553-7. PMC: 22124. DOI: 10.1073/pnas.96.13.7553. View

Zheng J, Trudeau M, Zagotta W . Rod cyclic nucleotide-gated channels have a stoichiometry of three CNGA1 subunits and one CNGB1 subunit. Neuron. 2002; 36(5):891-6. DOI: 10.1016/s0896-6273(02)01099-1. View

Munger S, Lane A, Zhong H, Leinders-Zufall T, Yau K, Zufall F . Central role of the CNGA4 channel subunit in Ca2+-calmodulin-dependent odor adaptation. Science. 2001; 294(5549):2172-5. PMC: 2885906. DOI: 10.1126/science.1063224. View

Zhou L, Siegelbaum S . Gating of HCN channels by cyclic nucleotides: residue contacts that underlie ligand binding, selectivity, and efficacy. Structure. 2007; 15(6):655-70. PMC: 1995447. DOI: 10.1016/j.str.2007.04.012. View

Sundin O, Yang J, Li Y, Zhu D, Hurd J, Mitchell T . Genetic basis of total colourblindness among the Pingelapese islanders. Nat Genet. 2000; 25(3):289-93. DOI: 10.1038/77162. View

Taylor S, Kim C, Vigil D, Haste N, Yang J, Wu J . Dynamics of signaling by PKA. Biochim Biophys Acta. 2005; 1754(1-2):25-37. DOI: 10.1016/j.bbapap.2005.08.024. View

Hofmann F, Biel M, Kaupp U . International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels. Pharmacol Rev. 2005; 57(4):455-62. DOI: 10.1124/pr.57.4.8. View

10.

Pape H . Queer current and pacemaker: the hyperpolarization-activated cation current in neurons. Annu Rev Physiol. 1996; 58:299-327. DOI: 10.1146/annurev.ph.58.030196.001503. View

11.

Bos J . Epac proteins: multi-purpose cAMP targets. Trends Biochem Sci. 2006; 31(12):680-6. DOI: 10.1016/j.tibs.2006.10.002. View

12.

Michels G, Er F, Khan I, Sudkamp M, Herzig S, Hoppe U . Single-channel properties support a potential contribution of hyperpolarization-activated cyclic nucleotide-gated channels and If to cardiac arrhythmias. Circulation. 2005; 111(4):399-404. DOI: 10.1161/01.CIR.0000153799.65783.3A. View

13.

Notomi T, Shigemoto R . Immunohistochemical localization of Ih channel subunits, HCN1-4, in the rat brain. J Comp Neurol. 2004; 471(3):241-76. DOI: 10.1002/cne.11039. View

14.

Kurahashi T, Menini A . Mechanism of odorant adaptation in the olfactory receptor cell. Nature. 1997; 385(6618):725-9. DOI: 10.1038/385725a0. View

15.

Wainger B, DeGennaro M, Santoro B, Siegelbaum S, Tibbs G . Molecular mechanism of cAMP modulation of HCN pacemaker channels. Nature. 2001; 411(6839):805-10. DOI: 10.1038/35081088. View

16.

Vasilyev D, Shan Q, Lee Y, Mayer S, Bowlby M, Strassle B . Direct inhibition of Ih by analgesic loperamide in rat DRG neurons. J Neurophysiol. 2007; 97(5):3713-21. DOI: 10.1152/jn.00841.2006. View

17.

Mistrik P, Mader R, Michalakis S, Weidinger M, Pfeifer A, Biel M . The murine HCN3 gene encodes a hyperpolarization-activated cation channel with slow kinetics and unique response to cyclic nucleotides. J Biol Chem. 2005; 280(29):27056-61. DOI: 10.1074/jbc.M502696200. View

18.

Knaus A, Zong X, Beetz N, Jahns R, Lohse M, Biel M . Direct inhibition of cardiac hyperpolarization-activated cyclic nucleotide-gated pacemaker channels by clonidine. Circulation. 2007; 115(7):872-80. DOI: 10.1161/CIRCULATIONAHA.106.667675. View

19.

Bareil C, Hamel C, Delague V, Arnaud B, Demaille J, Claustres M . Segregation of a mutation in CNGB1 encoding the beta-subunit of the rod cGMP-gated channel in a family with autosomal recessive retinitis pigmentosa. Hum Genet. 2001; 108(4):328-34. DOI: 10.1007/s004390100496. View

20.

Yu F, Yarov-Yarovoy V, Gutman G, Catterall W . Overview of molecular relationships in the voltage-gated ion channel superfamily. Pharmacol Rev. 2005; 57(4):387-95. DOI: 10.1124/pr.57.4.13. View