Direct Three-dimensional Printed Egg White Hydrogel Wound Dressing Promotes Wound Healing with Hitching Adipose Stem Cells

Overview

Journal Front Bioeng Biotechnol

Date 2022 Sep 8

PMID 36072289

Authors

Xinhui Wang

Yuan Ma

Xingtang Niu

Ting Su

Xiaoqi Huang

Feng Lu

Qiang Chang

Affiliations

Soon will be listed here.

Abstract

Current wound dressing based on hydrogel offers a promising way to accelerate the healing process, yet great challenges remain in the development of a highly integrated and efficient platform with the combination of therapeutic biomolecules and stem cells. Herein, a natural hydrogel wound dressing from egg white can be conveniently obtained by feasible physical crosslinking, the prepared hydrogel dressing features interconnected microporous channels, direct 3D printing, cytocompatibility, and intrinsic biomolecules to advance cell behavior. The 3D printed egg white hydrogels promote the adhesion and proliferation of adipose-derived stem cells (ASCs) without obvious cytotoxicity. In addition, this integrated hydrogel platform accompanied with adipose-derived stem cells accelerates wound healing through the enhancement of fibroblast proliferation, angiogenesis, and collagen rearrangement in the wound bed. The egg white hydrogel provides an effective wound caring product possessing low cost, easy availability along with ready manufacturing, and advanced therapeutic effect, which may be extended for the management of chronic or other complicated wounds.

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